Tumescent anesthesia in skin- and nipple-sparing mastectomy: Results of a prospective clinical study

Marco Gipponi, Ilaria Baldelli, Giulia Atzori, Piero Fregatti, Federica Murelli, Marianna Pesce, Cecilia Margarino, Francesca Depaoli, Daniele Friedman

Research output: Contribution to journalArticlepeer-review


Background: The tumescent mastectomy technique has been used to facilitate dissection of subcutaneous tissue and mammary gland in order to reduce intraoperative bleeding and speed the operation. Patients and Methods: A prospective clinical study was performed on 30 female patients undergoing immediate breast reconstructions after skin-sparing mastectomy (SSM) or nipple-sparing mastectomy (NSM) in order to assess early postoperative complications, pain, and final esthetic outcome of skin flaps related to tumescent anesthesia (TA). Results: TA significantly speeded-up the operative procedure (131±49.99 vs. 180.5±67.15 min; p=0.03) achieving less skin damage compared to patients who did not have TA (p=0.045); moreover, no significant difference occurred with regard to the length of in-hospital stay and overall lymphatic drainage. Conclusion: The length of the operation as well as the final cosmetic outcome of skin flaps was significantly improved due to TA, with no appreciable side-effects.

Original languageEnglish
Pages (from-to)349-352
Number of pages4
JournalAnticancer Research
Issue number1
Publication statusPublished - Jan 1 2017


  • Breast cancer
  • Breast reconstruction
  • Tumescent anesthesia

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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