Tumor antigen CA 125 as a marker of ovarian epithelial carcinoma

F. Zanaboni, F. Vergadoro, M. Presti, P. Gallotti, F. Lombardi, G. Bolis

Research output: Contribution to journalArticle

Abstract

Serum CA 125 was measured in 100 patients with ovarian epithelial carcinoma at diagnosis and in follow-up. Levels over 35 U/ml were found in 43 (75.4%) of 57 cases at diagnosis and in 21 (48.8%) of 43 cases in follow-up. A correlation was found between tumor burden and marker positivity: advanced Stages (III and IV) and recurrences had 84.2 and 91% of positivity, compared to 59.1% in early disease (Stages I and II). Analysis by histotype and FIGO grade revealed a difference between the mucinous type and the others and a positive association with less differentiated tumors. In the 30 patients submitted to second-look laparotomy a correlation was found between CA 125 levels and pathological response in 86.7% of cases. This ovarian cancer marker may thus be more useful in monitoring the response to treatment and in long-term follow-up than in diagnosis.

Original languageEnglish
Pages (from-to)61-67
Number of pages7
JournalGynecologic Oncology
Volume28
Issue number1
DOIs
Publication statusPublished - 1987

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Neoplasm Antigens
Carcinoma
Tumor Biomarkers
Tumor Burden
Ovarian Neoplasms
Laparotomy
Recurrence
Serum
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

Cite this

Zanaboni, F., Vergadoro, F., Presti, M., Gallotti, P., Lombardi, F., & Bolis, G. (1987). Tumor antigen CA 125 as a marker of ovarian epithelial carcinoma. Gynecologic Oncology, 28(1), 61-67. https://doi.org/10.1016/S0090-8258(87)80009-4

Tumor antigen CA 125 as a marker of ovarian epithelial carcinoma. / Zanaboni, F.; Vergadoro, F.; Presti, M.; Gallotti, P.; Lombardi, F.; Bolis, G.

In: Gynecologic Oncology, Vol. 28, No. 1, 1987, p. 61-67.

Research output: Contribution to journalArticle

Zanaboni, F, Vergadoro, F, Presti, M, Gallotti, P, Lombardi, F & Bolis, G 1987, 'Tumor antigen CA 125 as a marker of ovarian epithelial carcinoma', Gynecologic Oncology, vol. 28, no. 1, pp. 61-67. https://doi.org/10.1016/S0090-8258(87)80009-4
Zanaboni F, Vergadoro F, Presti M, Gallotti P, Lombardi F, Bolis G. Tumor antigen CA 125 as a marker of ovarian epithelial carcinoma. Gynecologic Oncology. 1987;28(1):61-67. https://doi.org/10.1016/S0090-8258(87)80009-4
Zanaboni, F. ; Vergadoro, F. ; Presti, M. ; Gallotti, P. ; Lombardi, F. ; Bolis, G. / Tumor antigen CA 125 as a marker of ovarian epithelial carcinoma. In: Gynecologic Oncology. 1987 ; Vol. 28, No. 1. pp. 61-67.
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AU - Bolis, G.

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