Myeloid cells infiltrating tumor tissues are key promoters of the reactive inflammatory microenvironment. Tumor-associated macrophages (TAM) are functionally conditioned by neoplastic and stromal cells and differentiate into pro-tumoral effectors. TAM promote disease progression by supporting cancer cell survival, proliferation, invasion, angiogenesis, and suppression of adaptive immune responses. Clinical and experimental evidence has shown that high TAM density is mostly associated with poor patient prognosis and resistance to therapies. Targeting of myeloid cells in tumors is considered a promising therapeutic strategy: depletion of TAM or their re-education as antitumor effectors is under clinical investigation and hopefully will contribute to the efficacy of conventional anti-cancer treatments.
|Title of host publication||Macrophages: Biology and Role in the Pathology of Diseases|
|Publisher||Springer New York|
|Number of pages||19|
|ISBN (Print)||9781493913114, 1493913107, 9781493913107|
|Publication status||Published - May 1 2014|
ASJC Scopus subject areas
- Immunology and Microbiology(all)