Abstract
The "macrophage balance hypothesis" was proposed in the early 1990s to depict the complex relationship that tumor-associated macrophages (TAM) have with the neoplastic cells of the tumor. TAM represent a prominent component of the mononuclear leukocyte population of solid tumors, which displays an ambivalent relationship with tumors. They originate in the circulation and are recruited to the tumor site by tumor-derived attractants such as chemokines and interact with the tumor cells and preferentially localize at the tumor-host tissue interface, in regions often associated with low oxygen tensions. The tumor microenvironment, including cytokines and hypoxia, regulates the localization and function of TAM. Emerging evidence starts to define the molecular basis for the peculiar functional phenotype of TAM and identifies possible therapeutic targets.
| Original language | English |
|---|---|
| Pages (from-to) | 1045-1054 |
| Number of pages | 10 |
| Journal | International Immunopharmacology |
| Volume | 2 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2002 |
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Keywords
- Molecular perspective
- Therapeutic target
- Tumor-associated macrophages
ASJC Scopus subject areas
- Immunology
- Pharmacology
Cite this
Tumor-associated macrophages : A molecular perspective. / Sica, Antonio; Saccani, Alessandra; Mantovani, Alberto.
In: International Immunopharmacology, Vol. 2, No. 8, 2002, p. 1045-1054.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tumor-associated macrophages
T2 - A molecular perspective
AU - Sica, Antonio
AU - Saccani, Alessandra
AU - Mantovani, Alberto
PY - 2002
Y1 - 2002
N2 - The "macrophage balance hypothesis" was proposed in the early 1990s to depict the complex relationship that tumor-associated macrophages (TAM) have with the neoplastic cells of the tumor. TAM represent a prominent component of the mononuclear leukocyte population of solid tumors, which displays an ambivalent relationship with tumors. They originate in the circulation and are recruited to the tumor site by tumor-derived attractants such as chemokines and interact with the tumor cells and preferentially localize at the tumor-host tissue interface, in regions often associated with low oxygen tensions. The tumor microenvironment, including cytokines and hypoxia, regulates the localization and function of TAM. Emerging evidence starts to define the molecular basis for the peculiar functional phenotype of TAM and identifies possible therapeutic targets.
AB - The "macrophage balance hypothesis" was proposed in the early 1990s to depict the complex relationship that tumor-associated macrophages (TAM) have with the neoplastic cells of the tumor. TAM represent a prominent component of the mononuclear leukocyte population of solid tumors, which displays an ambivalent relationship with tumors. They originate in the circulation and are recruited to the tumor site by tumor-derived attractants such as chemokines and interact with the tumor cells and preferentially localize at the tumor-host tissue interface, in regions often associated with low oxygen tensions. The tumor microenvironment, including cytokines and hypoxia, regulates the localization and function of TAM. Emerging evidence starts to define the molecular basis for the peculiar functional phenotype of TAM and identifies possible therapeutic targets.
KW - Molecular perspective
KW - Therapeutic target
KW - Tumor-associated macrophages
UR - http://www.scopus.com/inward/record.url?scp=0035993208&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035993208&partnerID=8YFLogxK
U2 - 10.1016/S1567-5769(02)00064-4
DO - 10.1016/S1567-5769(02)00064-4
M3 - Article
C2 - 12349942
AN - SCOPUS:0035993208
VL - 2
SP - 1045
EP - 1054
JO - International Immunopharmacology
JF - International Immunopharmacology
SN - 1567-5769
IS - 8
ER -