Tumor-associated macrophages and anti-tumor therapies: complex links

Cristina Belgiovine, Maurizio D’Incalci, Paola Allavena, Roberta Frapolli

Research output: Contribution to journalArticlepeer-review


Myeloid cells infiltrating the tumor microenvironment, especially tumor-associated macrophages (TAMs), are essential providers of cancer-related inflammation, a condition known to accelerate tumor progression and limit the response to anti-tumor therapies. As a matter of fact, TAMs may have a dual role while interfering with cancer treatments, as they can either promote or impair their functionality. Here we review the connection between macrophages and anticancer therapies; moreover, we provide an overview of the different strategies to target or re-program TAMs for therapeutic purposes.

Original languageEnglish
Pages (from-to)1-14
Number of pages14
JournalCellular and Molecular Life Sciences
Publication statusAccepted/In press - Mar 8 2016


  • Anti-tumor therapies
  • Cancer-related inflammation
  • Macrophage targeting
  • Nanoparticles
  • Tumor-associated macrophages

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine
  • Pharmacology
  • Cellular and Molecular Neuroscience


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