Tumor-associated macrophages and anti-tumor therapies

complex links

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Myeloid cells infiltrating the tumor microenvironment, especially tumor-associated macrophages (TAMs), are essential providers of cancer-related inflammation, a condition known to accelerate tumor progression and limit the response to anti-tumor therapies. As a matter of fact, TAMs may have a dual role while interfering with cancer treatments, as they can either promote or impair their functionality. Here we review the connection between macrophages and anticancer therapies; moreover, we provide an overview of the different strategies to target or re-program TAMs for therapeutic purposes.

Original languageEnglish
Pages (from-to)1-14
Number of pages14
JournalCellular and Molecular Life Sciences
DOIs
Publication statusAccepted/In press - Mar 8 2016

Fingerprint

Macrophages
Neoplasms
Therapeutics
Tumor Microenvironment
Myeloid Cells
Inflammation

Keywords

  • Anti-tumor therapies
  • Cancer-related inflammation
  • Macrophage targeting
  • Nanoparticles
  • Tumor-associated macrophages

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine
  • Pharmacology
  • Cellular and Molecular Neuroscience

Cite this

@article{860016270d8042ce86dec51d6141e947,
title = "Tumor-associated macrophages and anti-tumor therapies: complex links",
abstract = "Myeloid cells infiltrating the tumor microenvironment, especially tumor-associated macrophages (TAMs), are essential providers of cancer-related inflammation, a condition known to accelerate tumor progression and limit the response to anti-tumor therapies. As a matter of fact, TAMs may have a dual role while interfering with cancer treatments, as they can either promote or impair their functionality. Here we review the connection between macrophages and anticancer therapies; moreover, we provide an overview of the different strategies to target or re-program TAMs for therapeutic purposes.",
keywords = "Anti-tumor therapies, Cancer-related inflammation, Macrophage targeting, Nanoparticles, Tumor-associated macrophages",
author = "Cristina Belgiovine and Maurizio D’Incalci and Paola Allavena and Roberta Frapolli",
year = "2016",
month = "3",
day = "8",
doi = "10.1007/s00018-016-2166-5",
language = "English",
pages = "1--14",
journal = "Cellular and Molecular Life Sciences",
issn = "1420-682X",
publisher = "Birkhauser Verlag Basel",

}

TY - JOUR

T1 - Tumor-associated macrophages and anti-tumor therapies

T2 - complex links

AU - Belgiovine, Cristina

AU - D’Incalci, Maurizio

AU - Allavena, Paola

AU - Frapolli, Roberta

PY - 2016/3/8

Y1 - 2016/3/8

N2 - Myeloid cells infiltrating the tumor microenvironment, especially tumor-associated macrophages (TAMs), are essential providers of cancer-related inflammation, a condition known to accelerate tumor progression and limit the response to anti-tumor therapies. As a matter of fact, TAMs may have a dual role while interfering with cancer treatments, as they can either promote or impair their functionality. Here we review the connection between macrophages and anticancer therapies; moreover, we provide an overview of the different strategies to target or re-program TAMs for therapeutic purposes.

AB - Myeloid cells infiltrating the tumor microenvironment, especially tumor-associated macrophages (TAMs), are essential providers of cancer-related inflammation, a condition known to accelerate tumor progression and limit the response to anti-tumor therapies. As a matter of fact, TAMs may have a dual role while interfering with cancer treatments, as they can either promote or impair their functionality. Here we review the connection between macrophages and anticancer therapies; moreover, we provide an overview of the different strategies to target or re-program TAMs for therapeutic purposes.

KW - Anti-tumor therapies

KW - Cancer-related inflammation

KW - Macrophage targeting

KW - Nanoparticles

KW - Tumor-associated macrophages

UR - http://www.scopus.com/inward/record.url?scp=84960128329&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84960128329&partnerID=8YFLogxK

U2 - 10.1007/s00018-016-2166-5

DO - 10.1007/s00018-016-2166-5

M3 - Article

SP - 1

EP - 14

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

SN - 1420-682X

ER -