Tumor-associated macrophages and dendritic cells as prototypic type II polarized myeloid populations

Alberto Mantovani, Tiziana Schioppa, Subhra K. Biswas, Federica Marchesi, Paola Allavena, Antonio Sica

Research output: Contribution to journalArticlepeer-review

Abstract

Environmental signals polarize mononuclear phagocytes which can express different functional programmes. Fully polarized type I and type II (or alternatively activated) macrophages are the extremes of a continuum of functional states. Tumor-derived and T cell-derived cytokines stimulate tumor associated macrophages (TAM) to acquire a polarized type II phenotype. These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, play a key role in subversion of adaptive immunity and in inflammatory circuits which promote tumor growth and progression.

Original languageEnglish
Pages (from-to)459-468
Number of pages10
JournalTumori
Volume89
Issue number5
Publication statusPublished - Sep 2003

Keywords

  • Dendritic cells inflammation
  • Immunity
  • Tumors macrophages

ASJC Scopus subject areas

  • Cancer Research

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