Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation

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Abstract

Macrophages undergo a wide spectrum of polarized activation states, and have the potential both to elicit tumor and tissue destructive reactions and to promote tumor progression (macrophage balance). In general, tumor-associated macrophages (TAM) from established tumors and the related myeloid-derived suppressor cells are diverse and have properties of M2-activated cells. As such, they help cancer progression and metastasis. Therefore, TAM are a key component of pathways connecting inflammation and cancer.

Original languageEnglish
Pages (from-to)325-330
Number of pages6
JournalHuman Immunology
Volume70
Issue number5
DOIs
Publication statusPublished - May 2009

Keywords

  • Cancer
  • Cancer-related inflammation
  • Cytokines
  • Inflammation
  • Macrophages
  • Monocytes
  • Myeloid-derived suppressor cells
  • Polarization

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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