Tumor-associated macrophages as major source of APRIL in gastric MALT lymphoma

Fabio Munari, Silvia Lonardi, Marco A. Cassatella, Claudio Doglioni, Maria Giulia Cangi, Amedeo Amedei, Fabio Facchetti, Yoshinobu Eishi, Massimo Rugge, Matteo Fassan, Marina De Bernard, Mario M. D'Elios, William Vermi

Research output: Contribution to journalArticlepeer-review

Abstract

Lymphoid hyperplasia of gastric mucosa associated with Helicobacter pylori (HP) infection represents a preneoplastic condition of the mucosa associated lymphoid tissue (MALT), which may evolve to a B-cell lymphoma. While it is well established that the initial neoplastic proliferation of B cells is antigen-driven and dependent on the helper activity of HP-specific T cells, it needs to be elucidated which cytokine or soluble factor(s) promote Bcell activation and lymphomagenesis. Herein, we originally report that gastric MALT lymphoma express high levels of a proliferation inducing ligand (APRIL), a novel cytokine crucial in sustaining B-cell proliferation. By immunohistochemistry, we demonstrate that APRIL is produced almost exclusively by gastric lymphoma-infiltrating macrophages located in close proximity to neoplastic B cells. We also show that macrophages produce APRIL on direct stimulation with both HP and HP-specific T cells. Collectively, our results represent the first evidence for an involvement of APRIL in gastric MALT lymphoma development in HP-infected patients.

Original languageEnglish
Pages (from-to)6612-6616
Number of pages5
JournalBlood
Volume117
Issue number24
DOIs
Publication statusPublished - Jun 16 2011

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

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