Tumor-associated Macrophages in Cancer Growth and Progression

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Tumor development and progression are strongly linked to inflammation and macrophage infiltration is a major component of the inflammatory reactions associated with neoplasia. Plasticity is a hallmark of mononuclear phagocytes, which undergo polarized diverse forms of activation. Metabolic adaptation is a key component of macrophage plasticity and polarization, instrumental to their function in homeostasis, immunity and inflammation. Tumor-associated macrophages (TAM) and related immature myeloid suppressor cells generally have properties of an M2-like population. TAM produce growth factors, have immunoregulatory and immunosuppressive activity, stimulate angiogenesis and provide tissue remodeling, invasion and metastasis. Thus, TAM are a key component of cancer-promoting inflammatory reactions.

Original languageEnglish
Title of host publicationCancer Immunotherapy: Immune Suppression and Tumor Growth: Second Edition
PublisherElsevier Inc.
Pages451-471
Number of pages21
ISBN (Print)9780123942968
DOIs
Publication statusPublished - Jul 2013

Keywords

  • Adaptive immunity
  • Angiogenesis
  • Cancer-related inflammation
  • Chemokines
  • Cytokines
  • Macrophage plasticity
  • Macrophage polarization
  • Matrix remodeling
  • Metabolic adaptation
  • Tumor progression

ASJC Scopus subject areas

  • Medicine(all)
  • Dentistry(all)

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