Abstract
Experimental and epidemiological studies indicate a strong link between chronic inflammation and tumor progression. Human colorectal cancer (CRC), a major cause of cancer-related death in Western countries, represents a paradigm for this link. Key features of cancer-related inflammation in CRC are the activation of transcription factors (e.g. NF-?B, STAT3), the expression of inflammatory cytokines and chemokines (e.g. TNFa, IL-6, CCL2, CXCL8) as well as a prominent leukocyte infiltrate. While considerable evidence indicates that the presence of lymphocytes of adaptive immunity may positively influence patient survival and clinical outcome in CRC, the role of tumor-associated macrophages (TAM) and of other lymphoid populations (e.g. Th17, Treg) is still unclear. In this review we will summarize the different and controversial effects that TAM play in CRC-related inflammation and progression of disease. The characterization of the most relevant inflammatory pathways in CRC is instrumental for the identification of new target molecules that could lead to improved diagnosis and treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 141-154 |
| Number of pages | 14 |
| Journal | Cancer Microenvironment |
| Volume | 4 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Aug 2011 |
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Keywords
- Chemokines
- Colorectal cancer
- Cytokines
- Inflammation
- Tumor-associated macrophages
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Tumor-associated macrophages (TAM) and inflammation in colorectal cancer. / Erreni, Marco; Mantovani, Alberto; Allavena, Paola.
In: Cancer Microenvironment, Vol. 4, No. 2, 08.2011, p. 141-154.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tumor-associated macrophages (TAM) and inflammation in colorectal cancer
AU - Erreni, Marco
AU - Mantovani, Alberto
AU - Allavena, Paola
PY - 2011/8
Y1 - 2011/8
N2 - Experimental and epidemiological studies indicate a strong link between chronic inflammation and tumor progression. Human colorectal cancer (CRC), a major cause of cancer-related death in Western countries, represents a paradigm for this link. Key features of cancer-related inflammation in CRC are the activation of transcription factors (e.g. NF-?B, STAT3), the expression of inflammatory cytokines and chemokines (e.g. TNFa, IL-6, CCL2, CXCL8) as well as a prominent leukocyte infiltrate. While considerable evidence indicates that the presence of lymphocytes of adaptive immunity may positively influence patient survival and clinical outcome in CRC, the role of tumor-associated macrophages (TAM) and of other lymphoid populations (e.g. Th17, Treg) is still unclear. In this review we will summarize the different and controversial effects that TAM play in CRC-related inflammation and progression of disease. The characterization of the most relevant inflammatory pathways in CRC is instrumental for the identification of new target molecules that could lead to improved diagnosis and treatment.
AB - Experimental and epidemiological studies indicate a strong link between chronic inflammation and tumor progression. Human colorectal cancer (CRC), a major cause of cancer-related death in Western countries, represents a paradigm for this link. Key features of cancer-related inflammation in CRC are the activation of transcription factors (e.g. NF-?B, STAT3), the expression of inflammatory cytokines and chemokines (e.g. TNFa, IL-6, CCL2, CXCL8) as well as a prominent leukocyte infiltrate. While considerable evidence indicates that the presence of lymphocytes of adaptive immunity may positively influence patient survival and clinical outcome in CRC, the role of tumor-associated macrophages (TAM) and of other lymphoid populations (e.g. Th17, Treg) is still unclear. In this review we will summarize the different and controversial effects that TAM play in CRC-related inflammation and progression of disease. The characterization of the most relevant inflammatory pathways in CRC is instrumental for the identification of new target molecules that could lead to improved diagnosis and treatment.
KW - Chemokines
KW - Colorectal cancer
KW - Cytokines
KW - Inflammation
KW - Tumor-associated macrophages
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UR - http://www.scopus.com/inward/citedby.url?scp=81855166109&partnerID=8YFLogxK
U2 - 10.1007/s12307-010-0052-5
DO - 10.1007/s12307-010-0052-5
M3 - Article
C2 - 21909876
AN - SCOPUS:81855166109
VL - 4
SP - 141
EP - 154
JO - Cancer Microenvironment
JF - Cancer Microenvironment
SN - 1875-2292
IS - 2
ER -