Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation

Research output: Contribution to journalArticle

Abstract

The microenvironment of solid tumors is characterized by a reactive stroma with an abundance of inflammatory mediators and leukocytes, dysregulated vessels and proteolytic enzymes. TAM, major players in the connection between inflammation and cancer, summarize a number of functions (e.g., promotion of tumor cell proliferation and angiogenesis, incessant matrix turnover, repression of adaptive immunity), which ultimately have an important impact on disease progression. Thus, together with other myeloid-related cells present at the tumor site (Tie2 macrophages and MDSCs), TAM represent an attractive target of novel biological therapies of tumors.

Original languageEnglish
Pages (from-to)1065-1073
Number of pages9
JournalJournal of Leukocyte Biology
Volume86
Issue number5
DOIs
Publication statusPublished - Nov 2009

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

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