Tumor-associated macrophages (TAMs) as new target in anticancer therapy

Alberto Mantovani, Chiara Porta, Luca Rubino, Paola Allavena, Antonio Sica

Research output: Contribution to journalArticlepeer-review

Abstract

The proposed connection between inflammation and cancer has recently found new molecular confirmations suggesting that the inflammatory circuits expressed at the tumor site are potential targets of antitumor therapy. Tumor-associated macrophages (TAMs) represent the major component of the inflammatory infiltrate of tumors and several lines of evidence suggest that these cells express protumoral functions amenable of therapeutic intervention. These include TAM activation, recruitment, angiogenesis and survival.

Original languageEnglish
Pages (from-to)361-366
Number of pages6
JournalDrug Discovery Today: Therapeutic Strategies
Volume3
Issue number3
DOIs
Publication statusPublished - 2006

ASJC Scopus subject areas

  • Drug Discovery
  • Molecular Medicine

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