Abstract
Background/Aims: Recently, early gastric cancers without lymph node metastasis have successfully been removed through a simple endoscopic resection. Tumor cell proliferation may be related to the malignant potential of early gastric cancer. The purpose of this study is to perspectively investigate the relationship between the incorporation rate of bromodeoxyuridine (BrdU) into the DNA of dividing cells, and the main biological and clinical early gastric cancer characteristics. Methodology: Multiple tumor specimens were taken from 27 early gastric cancers and analyzed through anti-BrdU monoclonal antibody. Tumor BrdU labeling index (LI=% positive cells over 2,000 tumor cells) was determined. Early gastric cancers were evaluated in tumor size, mucosal and submucosal involvement, histologic type and grading, lymphatic and venous invasion, and nodal metastasis. Results: BrdU LI was significantly higher in patients with submucosal neoplastic invasion, Pen A Kodama type, tumor vessel invasion and lymph node involvement. Early gastric cancer patients with over 22% BrdU LI showed a significantly higher incidence of submucosal invasion, lymphatic-venous involvement and a reduced survival when compared to patients with medium (12-22%) or low BrdU LI (
| Original language | English |
|---|---|
| Pages (from-to) | 264-268 |
| Number of pages | 5 |
| Journal | Hepato-Gastroenterology |
| Volume | 51 |
| Issue number | 55 |
| Publication status | Published - Jan 2004 |
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Keywords
- Bromodeoxyuridine
- Cellular proliferation
- Early gastric cancer
- Tumor growth
ASJC Scopus subject areas
- Gastroenterology
Cite this
Tumor Cell Proliferation in Early Gastric Cancer : Biological and Clinical Behavior. / Dionigi, Paolo; Ferrari, Alberta; Jemos, Vassili; Luinetti, Orietta; Vai, Luciano; Guizzetti, Michela; Ferrari, Cinzia; Jemos, Kostantinos; Spada, Marco; Mazzini, Giuliano.
In: Hepato-Gastroenterology, Vol. 51, No. 55, 01.2004, p. 264-268.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tumor Cell Proliferation in Early Gastric Cancer
T2 - Biological and Clinical Behavior
AU - Dionigi, Paolo
AU - Ferrari, Alberta
AU - Jemos, Vassili
AU - Luinetti, Orietta
AU - Vai, Luciano
AU - Guizzetti, Michela
AU - Ferrari, Cinzia
AU - Jemos, Kostantinos
AU - Spada, Marco
AU - Mazzini, Giuliano
PY - 2004/1
Y1 - 2004/1
N2 - Background/Aims: Recently, early gastric cancers without lymph node metastasis have successfully been removed through a simple endoscopic resection. Tumor cell proliferation may be related to the malignant potential of early gastric cancer. The purpose of this study is to perspectively investigate the relationship between the incorporation rate of bromodeoxyuridine (BrdU) into the DNA of dividing cells, and the main biological and clinical early gastric cancer characteristics. Methodology: Multiple tumor specimens were taken from 27 early gastric cancers and analyzed through anti-BrdU monoclonal antibody. Tumor BrdU labeling index (LI=% positive cells over 2,000 tumor cells) was determined. Early gastric cancers were evaluated in tumor size, mucosal and submucosal involvement, histologic type and grading, lymphatic and venous invasion, and nodal metastasis. Results: BrdU LI was significantly higher in patients with submucosal neoplastic invasion, Pen A Kodama type, tumor vessel invasion and lymph node involvement. Early gastric cancer patients with over 22% BrdU LI showed a significantly higher incidence of submucosal invasion, lymphatic-venous involvement and a reduced survival when compared to patients with medium (12-22%) or low BrdU LI (
AB - Background/Aims: Recently, early gastric cancers without lymph node metastasis have successfully been removed through a simple endoscopic resection. Tumor cell proliferation may be related to the malignant potential of early gastric cancer. The purpose of this study is to perspectively investigate the relationship between the incorporation rate of bromodeoxyuridine (BrdU) into the DNA of dividing cells, and the main biological and clinical early gastric cancer characteristics. Methodology: Multiple tumor specimens were taken from 27 early gastric cancers and analyzed through anti-BrdU monoclonal antibody. Tumor BrdU labeling index (LI=% positive cells over 2,000 tumor cells) was determined. Early gastric cancers were evaluated in tumor size, mucosal and submucosal involvement, histologic type and grading, lymphatic and venous invasion, and nodal metastasis. Results: BrdU LI was significantly higher in patients with submucosal neoplastic invasion, Pen A Kodama type, tumor vessel invasion and lymph node involvement. Early gastric cancer patients with over 22% BrdU LI showed a significantly higher incidence of submucosal invasion, lymphatic-venous involvement and a reduced survival when compared to patients with medium (12-22%) or low BrdU LI (
KW - Bromodeoxyuridine
KW - Cellular proliferation
KW - Early gastric cancer
KW - Tumor growth
UR - http://www.scopus.com/inward/record.url?scp=10744229737&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=10744229737&partnerID=8YFLogxK
M3 - Article
C2 - 15011882
AN - SCOPUS:10744229737
VL - 51
SP - 264
EP - 268
JO - Acta hepato-splenologica
JF - Acta hepato-splenologica
SN - 0172-6390
IS - 55
ER -