Tumor Cell Proliferation in Early Gastric Cancer: Biological and Clinical Behavior

Paolo Dionigi, Alberta Ferrari, Vassili Jemos, Orietta Luinetti, Luciano Vai, Michela Guizzetti, Cinzia Ferrari, Kostantinos Jemos, Marco Spada, Giuliano Mazzini

Research output: Contribution to journalArticlepeer-review


Background/Aims: Recently, early gastric cancers without lymph node metastasis have successfully been removed through a simple endoscopic resection. Tumor cell proliferation may be related to the malignant potential of early gastric cancer. The purpose of this study is to perspectively investigate the relationship between the incorporation rate of bromodeoxyuridine (BrdU) into the DNA of dividing cells, and the main biological and clinical early gastric cancer characteristics. Methodology: Multiple tumor specimens were taken from 27 early gastric cancers and analyzed through anti-BrdU monoclonal antibody. Tumor BrdU labeling index (LI=% positive cells over 2,000 tumor cells) was determined. Early gastric cancers were evaluated in tumor size, mucosal and submucosal involvement, histologic type and grading, lymphatic and venous invasion, and nodal metastasis. Results: BrdU LI was significantly higher in patients with submucosal neoplastic invasion, Pen A Kodama type, tumor vessel invasion and lymph node involvement. Early gastric cancer patients with over 22% BrdU LI showed a significantly higher incidence of submucosal invasion, lymphatic-venous involvement and a reduced survival when compared to patients with medium (12-22%) or low BrdU LI (

Original languageEnglish
Pages (from-to)264-268
Number of pages5
Issue number55
Publication statusPublished - Jan 2004


  • Bromodeoxyuridine
  • Cellular proliferation
  • Early gastric cancer
  • Tumor growth

ASJC Scopus subject areas

  • Gastroenterology


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