Tumor dormancy at bedside: A late awakening

Romano Demicheli, Christine Desmedt, Martine Piccart, Elia Biganzoli

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Breast cancer recurrence may occur at variable times following primary tumor removal. The corresponding event dynamics displays a structured multipeak pattern, which can be explained by the occurrence of microscopic phases of metastasis quiescence (tumor dormancy) followed by wake up, growth and timed clinical appearance. This model provides a meaningful justification of the early recurrence pattern and even explains the effectiveness of adjuvant systemic therapies. Yet, late recurrences, which were less investigated, are fairly little known and a few researchers supported their steady state appearance. We report here the analysis of the late clinical course from patients who were disease-free at 5 years of follow-up, which again displays a structured pattern, supporting the view that tumor dormancy can explain the late recurrence risk as well. Tailored treatments are needed to address late clinical recurrences.

Original languageEnglish
Pages (from-to)61-63
Number of pages3
JournalBreast
Volume45
DOIs
Publication statusPublished - Jun 2019

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Keywords

  • Breast cancer
  • Late recurrences
  • Recurrence dynamics
  • Tumor dormancy
  • Tumor homeostasis

ASJC Scopus subject areas

  • Surgery

Cite this

Tumor dormancy at bedside : A late awakening. / Demicheli, Romano; Desmedt, Christine; Piccart, Martine; Biganzoli, Elia.

In: Breast, Vol. 45, 06.2019, p. 61-63.

Research output: Contribution to journalArticle

Demicheli, Romano ; Desmedt, Christine ; Piccart, Martine ; Biganzoli, Elia. / Tumor dormancy at bedside : A late awakening. In: Breast. 2019 ; Vol. 45. pp. 61-63.
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