Tumor-extracellular matrix interactions: Identification of tools associated with breast cancer progression

Research output: Contribution to journalArticle

Abstract

Several evidences support the concept that cancer development and progression are not entirely cancer cell-autonomous processes, but may be influenced, and possibly driven, by cross-talk between cancer cells and the surrounding microenvironment in which, besides immune cells, stromal cells and extracellular matrix (ECM) play a major role in regulating distinct biologic processes. Stroma and ECM-related signatures proved to influence breast cancer progression, and to contribute to the identification of tumor phenotypes resistant to cytotoxic and hormonal treatments. The possible clinical implications of the interplay between tumor cells and the microenvironment, with special reference to ECM remodelling, will be discussed in this review.

Original languageEnglish
Pages (from-to)3-10
Number of pages8
JournalSeminars in Cancer Biology
Volume35
DOIs
Publication statusPublished - Dec 1 2015

Keywords

  • Breast cancer
  • ECM-related signatures
  • Extracellular matrix
  • Tumor microenvironment
  • Tumor stroma component

ASJC Scopus subject areas

  • Cancer Research

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