Abstract
Several evidences support the concept that cancer development and progression are not entirely cancer cell-autonomous processes, but may be influenced, and possibly driven, by cross-talk between cancer cells and the surrounding microenvironment in which, besides immune cells, stromal cells and extracellular matrix (ECM) play a major role in regulating distinct biologic processes. Stroma and ECM-related signatures proved to influence breast cancer progression, and to contribute to the identification of tumor phenotypes resistant to cytotoxic and hormonal treatments. The possible clinical implications of the interplay between tumor cells and the microenvironment, with special reference to ECM remodelling, will be discussed in this review.
| Original language | English |
|---|---|
| Pages (from-to) | 3-10 |
| Number of pages | 8 |
| Journal | Seminars in Cancer Biology |
| Volume | 35 |
| DOIs | |
| Publication status | Published - Dec 1 2015 |
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Keywords
- Breast cancer
- ECM-related signatures
- Extracellular matrix
- Tumor microenvironment
- Tumor stroma component
ASJC Scopus subject areas
- Cancer Research
Cite this
Tumor-extracellular matrix interactions : Identification of tools associated with breast cancer progression. / Giussani, Marta; Merlino, Giuseppe; Cappelletti, Vera; Tagliabue, Elda; Daidone, Maria Grazia.
In: Seminars in Cancer Biology, Vol. 35, 01.12.2015, p. 3-10.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tumor-extracellular matrix interactions
T2 - Identification of tools associated with breast cancer progression
AU - Giussani, Marta
AU - Merlino, Giuseppe
AU - Cappelletti, Vera
AU - Tagliabue, Elda
AU - Daidone, Maria Grazia
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Several evidences support the concept that cancer development and progression are not entirely cancer cell-autonomous processes, but may be influenced, and possibly driven, by cross-talk between cancer cells and the surrounding microenvironment in which, besides immune cells, stromal cells and extracellular matrix (ECM) play a major role in regulating distinct biologic processes. Stroma and ECM-related signatures proved to influence breast cancer progression, and to contribute to the identification of tumor phenotypes resistant to cytotoxic and hormonal treatments. The possible clinical implications of the interplay between tumor cells and the microenvironment, with special reference to ECM remodelling, will be discussed in this review.
AB - Several evidences support the concept that cancer development and progression are not entirely cancer cell-autonomous processes, but may be influenced, and possibly driven, by cross-talk between cancer cells and the surrounding microenvironment in which, besides immune cells, stromal cells and extracellular matrix (ECM) play a major role in regulating distinct biologic processes. Stroma and ECM-related signatures proved to influence breast cancer progression, and to contribute to the identification of tumor phenotypes resistant to cytotoxic and hormonal treatments. The possible clinical implications of the interplay between tumor cells and the microenvironment, with special reference to ECM remodelling, will be discussed in this review.
KW - Breast cancer
KW - ECM-related signatures
KW - Extracellular matrix
KW - Tumor microenvironment
KW - Tumor stroma component
UR - http://www.scopus.com/inward/record.url?scp=84948680447&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84948680447&partnerID=8YFLogxK
U2 - 10.1016/j.semcancer.2015.09.012
DO - 10.1016/j.semcancer.2015.09.012
M3 - Article
C2 - 26416466
AN - SCOPUS:84948680447
VL - 35
SP - 3
EP - 10
JO - Seminars in Cancer Biology
JF - Seminars in Cancer Biology
SN - 1044-579X
ER -