Tumor-induced alterations in lipid metabolism

Research output: Contribution to journalArticle

Abstract

Alterations of lipid metabolism have been increasingly recognized as a hallmark of cancer cells. Cancer cells esterify fatty acids predominantly to phospholipids, an essential component of cell membranes. The main pathway along which proliferating cells gain lipids for membrane synthesis is the endogenous mevalonate pathway. Increased synthesis of mevalonate and mevalonate-derived isoprenoids supports increased cell proliferation through activating growthregulatory proteins and oncoproteins and promoting DNA synthesis. The importance of a better knowledge of metabolic changes in lipogenic enzymes pathways, as well as of the role of each biochemical pathway in carcinogenesis, provides the rationale for in-depth study of the oncogenic signaling important for the initiation and progression of tumors. The dependence of tumor cells on a dysregulated lipid metabolism suggests that the proteins involved in this process may be excellent chemotherapeutic targets for cancer treatment. Here, we confirm the vital link between lipogenesis and cell proliferation, and our recent findings suggest that nutritional intervention is an effective and safe way to reduce cell proliferation in experimental models of carcinogenesis. The olive oil diet significantly reduces the protein activities of lipogenic enzymes associated with cell growth. The use of natural dietary components could potentially assist in the management of subjects with metabolic disorders-related tumors.

Original languageEnglish
Pages (from-to)2729-2733
Number of pages5
JournalCurrent Medicinal Chemistry
Volume21
Issue number24
DOIs
Publication statusPublished - 2014

Fingerprint

Mevalonic Acid
Cell proliferation
Lipid Metabolism
Tumors
Cells
Neoplasms
Proteins
Oncology
Oncogene Proteins
Terpenes
Cell Proliferation
Cell growth
Enzymes
Cell membranes
Membrane Lipids
Nutrition
Carcinogenesis
Fatty Acids
Lipogenesis
DNA

Keywords

  • Lipid metabolism
  • Tumor

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Medicine(all)

Cite this

Tumor-induced alterations in lipid metabolism. / Notarnicola, M.; Tutino, V.; Caruso, M. G.

In: Current Medicinal Chemistry, Vol. 21, No. 24, 2014, p. 2729-2733.

Research output: Contribution to journalArticle

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