TY - JOUR
T1 - Tumor-infiltrating lymphocytes in Breast Cancer and implications for clinical practice
AU - de Melo Gagliato, Debora
AU - Cortes, Javier
AU - Curigliano, Giuseppe
AU - Loi, Sherene
AU - Denkert, Carsten
AU - Perez-Garcia, Jose
AU - Holgado, Esther
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Breast Cancer (BC) can be classified using pathologic features, such as grade and tumor size. It can be categorized based on the gene expression profile, which identifies the distinct molecular subtype. More recently, stromal tissue has been recognized as an important modulator of tumor cell growth, pathogenesis, and progression. Immune cells could drive important clinical characteristics that affect BC outcomes. Subgroups of patients who have tumor-infiltrating lymphocytes in the stroma may have better response to chemotherapy and favorable long-term prognosis. Accumulating evidence shows that the immune system plays a crucial role in the outcomes of some BC subgroups, especially more aggressive, proliferative ones such as triple-negative and HER2-positive BC. This review article will present data on the role of lymphocyte infiltration in BC prognosis and response to therapy. This review will also introduce the reader to the challenges of applying this promising prognostic and predictive biomarker in clinical practice.
AB - Breast Cancer (BC) can be classified using pathologic features, such as grade and tumor size. It can be categorized based on the gene expression profile, which identifies the distinct molecular subtype. More recently, stromal tissue has been recognized as an important modulator of tumor cell growth, pathogenesis, and progression. Immune cells could drive important clinical characteristics that affect BC outcomes. Subgroups of patients who have tumor-infiltrating lymphocytes in the stroma may have better response to chemotherapy and favorable long-term prognosis. Accumulating evidence shows that the immune system plays a crucial role in the outcomes of some BC subgroups, especially more aggressive, proliferative ones such as triple-negative and HER2-positive BC. This review article will present data on the role of lymphocyte infiltration in BC prognosis and response to therapy. This review will also introduce the reader to the challenges of applying this promising prognostic and predictive biomarker in clinical practice.
KW - Breast Cancer
KW - Immune system
KW - Lymphocyte infiltration
KW - Response to chemotherapy
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U2 - 10.1016/j.bbcan.2017.10.003
DO - 10.1016/j.bbcan.2017.10.003
M3 - Review article
AN - SCOPUS:85032357521
VL - 1868
SP - 527
EP - 537
JO - Biochimica et Biophysica Acta - Reviews on Cancer
JF - Biochimica et Biophysica Acta - Reviews on Cancer
SN - 0304-419X
IS - 2
ER -