Tumor-infiltrating lymphocytes predict cutaneous melanoma survival

Cristina Fortes, Simona Mastroeni, Thomas J. Mannooranparampil, Francesca Passarelli, Alba Zappalà, Giorgio Annessi, Claudia Marino, Alessio Caggiati, Nicoletta Russo, Paola Michelozzi

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Abstract

Understanding differences in survival across distinct subgroups of melanoma patients may help with the choice of types of therapy. Tumor-infiltrating lymphocytes (TILs) are considered a manifestation of the host immune response to tumor, but the role of TILs in melanoma mortality is controversial. The aim of this study was to investigate independent prognostic factors for melanoma mortality. We carried out a 10-year cohort study on 4133 melanoma patients from the same geographic area (Lazio) with primary cutaneous melanoma diagnosed between January 1998 and December 2008. The probability of survival was estimated using Kaplan-Meier methods and prognostic factors were evaluated by multivariate analysis (Cox proportional hazards model). The 10-year survival rate for melanoma decreased with increasing Breslow thickness (P for trend

Original languageEnglish
Pages (from-to)306-311
Number of pages6
JournalMelanoma Research
Volume25
Issue number4
DOIs
Publication statusPublished - Jul 11 2015

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Keywords

  • melanoma
  • mortality
  • survival
  • tumor-infiltrating lymphocytes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Dermatology

Cite this

Fortes, C., Mastroeni, S., Mannooranparampil, T. J., Passarelli, F., Zappalà, A., Annessi, G., Marino, C., Caggiati, A., Russo, N., & Michelozzi, P. (2015). Tumor-infiltrating lymphocytes predict cutaneous melanoma survival. Melanoma Research, 25(4), 306-311. https://doi.org/10.1097/CMR.0000000000000164