Tumor-infiltrating myeloid cells drive senescence evasion and chemoresistance in tumors

Diletta Di Mitri, Alberto Toso, Andrea Alimonti

Research output: Contribution to journalArticle

Abstract

The present study supports a model in which Pten loss-induced senescence is hindered in prostate tumor cells by non cell-autonomous mechanisms. Indeed, paracrine signaling by tumor-infiltrating CD11b+Gr-1+ myeloid cells triggers senescence evasion in prostate lesions of Pten-null mice, eventually promoting tumor progression.

Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalOncoImmunology
Volume4
Issue number9
DOIs
Publication statusPublished - Jan 1 2015

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

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