Tumor-like multiple sclerosis: Report of four cases and literature review

Emanuela Caroli, Maurizio Salvati, Luigi Ferrante

Research output: Contribution to journalArticlepeer-review


Aims and background: Classical multiple sclerosis plaques usually have typical features on gadolinium-enhanced MRI scan. This non-neoplastic demyelinating process of the central nervous system generally does not produce focal space-occupying lesions associated with ring enhancement. However, atypical appearance of demyelinating lesions simulating a brain tumor is a possible well-known phenomenon. Methods: We present our experience with 4 cases of multiple sclerosis indistinguishable clinically and neuroradiologically from a cerebral tumor. All patients underwent surgery. Results: Histological examinations of all cases were positive for multiple sclerosis plaques. Conclusions: The presented cases demonstrate the importance of considering a demyelinating disease in the differential diagnosis of a tumor-like brain lesion.

Original languageEnglish
Pages (from-to)559-562
Number of pages4
Issue number6
Publication statusPublished - Nov 2006


  • Atypical multiple sclerosis
  • Brain tumor
  • Multiple sclerosis
  • Tumor-like multiple sclerosis plaque

ASJC Scopus subject areas

  • Cancer Research


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