Tumor markers and lung cancer: correlation between serum and bronchial secretion levels of CEA, TPA, CanAg CA-50, NSE and ferritin.

V. Macchia, A. Mariano, M. Cavalcanti, A. Coppa, C. Cecere, G. Fraioli, S. Elia, G. Ferrante

Research output: Contribution to journalArticle

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Abstract

The levels of carcinoembryonic antigeny (CEA), tissue polypeptide antigeny (TPA), CanAg 50, neuron specific enolase (NSE) and ferritin were determined in bronchial secretion and serum of patients with neoplastic and non-neoplastic lung diseases. Simultaneous determination of two or three markers in the serum and in bronchoalveolar lavage (BAL) may be clinically useful for the diagnosis of lung cancer and even for the type of tumor. The positivity of CEA determined simultaneously in serum and in BAL of patients with lung cancer is higher than 80% whereas in patients with benign lung disease it is lower than 40%. The simultaneous assay of TPA in serum and in BAL showed 100% positivity in patients with oat-cell carcinoma, the frequencies of positivity were similar in patients with non-oat-cell carcinoma. For NSE and CanAg CA-50 patients with oat-cell carcinoma showed 100% positivity. Simultaneous assay of ferritin in serum and in BAL gave 85% positivity in patients with oat-cell carcinoma and only 23% in patients with non-oat-cell carcinoma. We conclude that the simultaneous determination of CEA and CanAg CA-50 or NSE in serum and in BAL is a useful aid in the diagnosis of lung malignancy.

Original languageEnglish
Pages (from-to)151-156
Number of pages6
JournalInternational Journal of Biological Markers
Volume2
Issue number3
Publication statusPublished - Sep 1987

Fingerprint

Phosphopyruvate Hydratase
Ferritins
Tumor Biomarkers
Lung Neoplasms
Cells
Tissue
Bronchoalveolar Lavage
Peptides
Serum
Pulmonary diseases
Small Cell Carcinoma
Assays
Lung Diseases
Tumors
Carcinoma
Neoplasms
Biomarkers
Lung

ASJC Scopus subject areas

  • Biochemistry
  • Immunology

Cite this

Macchia, V., Mariano, A., Cavalcanti, M., Coppa, A., Cecere, C., Fraioli, G., ... Ferrante, G. (1987). Tumor markers and lung cancer: correlation between serum and bronchial secretion levels of CEA, TPA, CanAg CA-50, NSE and ferritin. International Journal of Biological Markers, 2(3), 151-156.

Tumor markers and lung cancer : correlation between serum and bronchial secretion levels of CEA, TPA, CanAg CA-50, NSE and ferritin. / Macchia, V.; Mariano, A.; Cavalcanti, M.; Coppa, A.; Cecere, C.; Fraioli, G.; Elia, S.; Ferrante, G.

In: International Journal of Biological Markers, Vol. 2, No. 3, 09.1987, p. 151-156.

Research output: Contribution to journalArticle

Macchia, V, Mariano, A, Cavalcanti, M, Coppa, A, Cecere, C, Fraioli, G, Elia, S & Ferrante, G 1987, 'Tumor markers and lung cancer: correlation between serum and bronchial secretion levels of CEA, TPA, CanAg CA-50, NSE and ferritin.', International Journal of Biological Markers, vol. 2, no. 3, pp. 151-156.
Macchia, V. ; Mariano, A. ; Cavalcanti, M. ; Coppa, A. ; Cecere, C. ; Fraioli, G. ; Elia, S. ; Ferrante, G. / Tumor markers and lung cancer : correlation between serum and bronchial secretion levels of CEA, TPA, CanAg CA-50, NSE and ferritin. In: International Journal of Biological Markers. 1987 ; Vol. 2, No. 3. pp. 151-156.
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