Tumor necrosis factor-α and interleukin-1 β: Two possible mediators of allergic inflammation

M. Pellegrino, B. Minervini, P. Musto, R. Matera, A. Greco, C. Checchia De Ambrosio

Research output: Contribution to journalArticle

Abstract

Serum levels of tumor necrosis factor-alpha (TNF-α), interleukin 1 beta (IL-1 β) and interleukin-2-(IL-2) were measured in 19 atopic subjects and in 8 healthy controls. TNF-α concentration was increased in atopic subjects and the increase was correlated with the severity of the disease in patients affected by atopic dermatitis. Increased plasma levels of IL-1 β were found only in symptomatic asthmatic subjects. No increase of serum IL-2 concentration was found in atopic subjects. The data suggest a possible role of TNF-α and IL-1 β in the pathophysiological mechanism of the allergic inflammation.

Original languageEnglish
Pages (from-to)309-312
Number of pages4
JournalMinerva Pediatrica
Volume48
Issue number7-8
Publication statusPublished - Jul 1996

Keywords

  • Allergic inflammation
  • Interleuchin 1
  • Interleuchin 2
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Pellegrino, M., Minervini, B., Musto, P., Matera, R., Greco, A., & Checchia De Ambrosio, C. (1996). Tumor necrosis factor-α and interleukin-1 β: Two possible mediators of allergic inflammation. Minerva Pediatrica, 48(7-8), 309-312.