Tumor necrosis factor α polymorphism C-850T is not associated with Alzheimer's disease and vascular dementia in an Italian population

Liana Terreni; Sergio Fogliarino; Pierluigi Quadri; Rosa Maria Ruggieri; Federico Piccoli; Mauro Tettamanti; Ugo Lucca; Gianluigi Forloni

doi:10.1016/S0304-3940(03)00434-8

Tumor necrosis factor α polymorphism C-850T is not associated with Alzheimer's disease and vascular dementia in an Italian population

Liana Terreni, Sergio Fogliarino, Pierluigi Quadri, Rosa Maria Ruggieri, Federico Piccoli, Mauro Tettamanti, Ugo Lucca, Gianluigi Forloni

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

A pathogenic role of inflammatory factors has been proposed both in Alzheimer's disease (AD) and vascular dementia (VD). A previous report indicated the presence of polymorphism C-850T of tumor necrosis factor (TNF) α as a genetic risk factor for VD and, associated with apolipoprotein E ε4, for AD. We have assessed the association between TNF-α polymorphism and dementias in Italian populations of AD, VD and elderly controls. The influence of TNF-α polymorphism on dementia has not been confirmed in this segment of the Italian population.

Original language	English
Pages (from-to)	135-137
Number of pages	3
Journal	Neuroscience Letters
Volume	344
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3940(03)00434-8
Publication status	Published - Jun 26 2003

Keywords

Apolipoprotein E
Cytokines
Dementia
Genetic risk
Neuroinflammation

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0304-3940(03)00434-8

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Tumor necrosis factor α polymorphism C-850T is not associated with Alzheimer's disease and vascular dementia in an Italian population. / Terreni, Liana; Fogliarino, Sergio; Quadri, Pierluigi; Ruggieri, Rosa Maria; Piccoli, Federico; Tettamanti, Mauro ; Lucca, Ugo ; Forloni, Gianluigi.

In: Neuroscience Letters, Vol. 344, No. 2, 26.06.2003, p. 135-137.

Research output: Contribution to journal › Article › peer-review

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abstract = "A pathogenic role of inflammatory factors has been proposed both in Alzheimer's disease (AD) and vascular dementia (VD). A previous report indicated the presence of polymorphism C-850T of tumor necrosis factor (TNF) α as a genetic risk factor for VD and, associated with apolipoprotein E ε4, for AD. We have assessed the association between TNF-α polymorphism and dementias in Italian populations of AD, VD and elderly controls. The influence of TNF-α polymorphism on dementia has not been confirmed in this segment of the Italian population.",

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AU - Terreni, Liana

AU - Fogliarino, Sergio

AU - Quadri, Pierluigi

AU - Ruggieri, Rosa Maria

AU - Piccoli, Federico

AU - Tettamanti, Mauro

AU - Lucca, Ugo

AU - Forloni, Gianluigi

PY - 2003/6/26

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N2 - A pathogenic role of inflammatory factors has been proposed both in Alzheimer's disease (AD) and vascular dementia (VD). A previous report indicated the presence of polymorphism C-850T of tumor necrosis factor (TNF) α as a genetic risk factor for VD and, associated with apolipoprotein E ε4, for AD. We have assessed the association between TNF-α polymorphism and dementias in Italian populations of AD, VD and elderly controls. The influence of TNF-α polymorphism on dementia has not been confirmed in this segment of the Italian population.

AB - A pathogenic role of inflammatory factors has been proposed both in Alzheimer's disease (AD) and vascular dementia (VD). A previous report indicated the presence of polymorphism C-850T of tumor necrosis factor (TNF) α as a genetic risk factor for VD and, associated with apolipoprotein E ε4, for AD. We have assessed the association between TNF-α polymorphism and dementias in Italian populations of AD, VD and elderly controls. The influence of TNF-α polymorphism on dementia has not been confirmed in this segment of the Italian population.

KW - Apolipoprotein E

KW - Cytokines

KW - Dementia

KW - Genetic risk

KW - Neuroinflammation

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Tumor necrosis factor α polymorphism C-850T is not associated with Alzheimer's disease and vascular dementia in an Italian population

Abstract

Keywords

ASJC Scopus subject areas

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