Tumor necrosis factor α polymorphism C-850T is not associated with Alzheimer's disease and vascular dementia in an Italian population

Liana Terreni, Sergio Fogliarino, Pierluigi Quadri, Rosa Maria Ruggieri, Federico Piccoli, Mauro Tettamanti, Ugo Lucca, Gianluigi Forloni

Research output: Contribution to journalArticle

Abstract

A pathogenic role of inflammatory factors has been proposed both in Alzheimer's disease (AD) and vascular dementia (VD). A previous report indicated the presence of polymorphism C-850T of tumor necrosis factor (TNF) α as a genetic risk factor for VD and, associated with apolipoprotein E ε4, for AD. We have assessed the association between TNF-α polymorphism and dementias in Italian populations of AD, VD and elderly controls. The influence of TNF-α polymorphism on dementia has not been confirmed in this segment of the Italian population.

Original languageEnglish
Pages (from-to)135-137
Number of pages3
JournalNeuroscience Letters
Volume344
Issue number2
DOIs
Publication statusPublished - Jun 26 2003

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Keywords

  • Apolipoprotein E
  • Cytokines
  • Dementia
  • Genetic risk
  • Neuroinflammation

ASJC Scopus subject areas

  • Neuroscience(all)

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