Tumor necrosis factor β and soluble APO-1/Fas independently predict progression to AIDS in HIV-seropositive patients

Francisco J. Medrano, Manuel Leal, Donatella Arienti, Concepcion Rey, Arianna Zagliani, Yolanda Torres, Armando Sanchez-Quijano, Eduardo Lissen, Mario Clerici

Research output: Contribution to journalArticlepeer-review

Abstract

The relationship between serum concentration of different components of the nerve growth factor/tumor necrosis factor (TNF) receptor family, including soluble APO-1/Fas (sAPO-1/Fas) and progression of HIV infection, was analyzed in a case-control study of individuals selected from a cohort of HIV-seropositive patients who were progressing or not progressing to AIDS while being treated with nucleoside analogs. HIV-seronegative healthy controls were also analyzed. The results showed that, despite close matching for immunologic (CD4 cell count, β2-microglobulin concentration) and virologic (p24 antigen, detection of HIV syncytium-inducing phenotype, plasma HIV viremia) parameters, the baseline serum concentrations of TNF-β and sAPO-1/Fas were statistically different between progressing and nonprogressing patients. In addition, serum concentrations of TNF-β and sAPO-1/Fas showed the strongest independent predictive power for progression to AIDS in a multivariate conditional logistic regression model. Because TNF- β and Fas were suggested to be mediators of antigen-induced cell death (AICD) in HIV infection and sAPO-1/Fas was hypothesized to protect lymphocyte against AICD, these data suggest an important pathogenetic role for AICD in the progression of HIV infection.

Original languageEnglish
Pages (from-to)835-843
Number of pages9
JournalAIDS Research and Human Retroviruses
Volume14
Issue number10
Publication statusPublished - Jul 1 1998

ASJC Scopus subject areas

  • Immunology
  • Virology

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