Tumor necrosis factor-alpha and myocardial function in patients with myotonic dystrophy type 1

Antonio Mammarella, Patrizia Ferroni, Michele Paradiso, Francesca Martini, Vincenzo Paoletti, Stefania Morino, Giovanni Antonini, Pier Paolo Gazzaniga, Antonino Musca, Stefania Basili

Research output: Contribution to journalArticlepeer-review

Abstract

An imbalance of TNF system activity has been reported in patients with myotonic dystrophy type 1 (DM1). Nevertheless, the question whether TNF-α action is directly implicated in the pathogenesis of DM1 or is a simple marker of disease activity is still open. Therefore, the present study was aimed to investigate serum tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 levels in association with the disease stage, cytosine-thymine-guanine (CTG) expansion and cardiac function of 56 patients with DM1 (40±14 years) and 28 healthy controls (42±12 years). All subjects were submitted to resting electrocardiogram (EKG), Signal-averaged EKG (SA-EKG), and M-mode/2-D echocardiography. TNF-α levels were higher in patients compared to controls (p

Original languageEnglish
Pages (from-to)59-64
Number of pages6
JournalJournal of the Neurological Sciences
Volume201
Issue number1-2
DOIs
Publication statusPublished - Sep 15 2002

Keywords

  • Cytokines
  • Diastolic function
  • Myotonic dystrophy type 1
  • QT-dispersion
  • Tumor necrosis factor-alpha
  • Ventricular late potentials

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

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