Tumor Necrosis Factor Alpha Differentially Regulates Beta- Endorphin Concentrations And Proopiomelanocortin Rna In The Anterior And Neurointermediate Pituitary In Vivo

Paola Sacerdote, Anna T. Brinia, Luisa Locatelli, Jelena Radulovic, Alberto E. Panerai

Research output: Contribution to journalArticle

Abstract

We analyzed the effect of tumor necrosis factor α (TNF- α) on β-endorphin concentrations and proopiomelanocortin mRNA in the rat anterior and neurointermediate pituitaries. The intraperitoneal injection of 5 μg/kg TNF- α decreases β-endorphin in neurointermediate pituicytes 4, 8 and 24 h after the treatment without affecting proopiomelanocortin (POMC) RNA. In contrast, in the anterior pituitary 4 h after the injection of the cytokine, POMC RNA was decreased while the peptide content was increased. These effects can be relevant to the modulation of the pituitary-adrenal axis and immune responses in conditions, such as infections, in which TNF levels are increased.

Original languageEnglish
Pages (from-to)357-360
Number of pages4
JournalNeuroImmunoModulation
Volume1
Issue number6
DOIs
Publication statusPublished - 1994

Keywords

  • Cytokines
  • Pituitary
  • Proopiomelanocortin
  • Tumor necrosis factor α
  • β-Endorphin

ASJC Scopus subject areas

  • Endocrinology
  • Immunology
  • Endocrine and Autonomic Systems
  • Neurology
  • Neuroscience(all)

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