Tumor necrosis factor-alpha gene -308G>A polymorphism is associated with ST-elevation myocardial infarction and with high plasma levels of biochemical ischemia markers

Roberto Antonicelli, Fabiola Olivieri, Luca Cavallone, Liana Spazzafumo, Massimiliano Bonafè, Francesca Marchegiani, Maurizio Cardelli, Roberta Galeazzi, Simona Giovagnetti, Gian Piero Perna, Claudio Franceschi

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVES: As is well known, acute myocardial infarction presents two electrocardiogram (EKG) patterns, ST-elevation (STEMI) and no ST-elevation (NSTEMI), characterized by different coronary artery thrombotic occlusion. Growing evidence shows that inflammation plays a central role in the pathogenesis of acute myocardial infarction. Among the factors that promote inflammation and arterial thrombosis, one of the most important is the proinflammatory cytokine tumor necrosis factor-α. The expression of this cytokine is modulated by a polymorphism located at nucleotide -308 of tumor necrosis factor-α promoter gene. The objective of our study is to verify whether tumor necrosis factor-α -308 polymorphism is associated with risk of acute myocardial infarction (STEMI and NSTEMI) or with biochemical myocardial ischemia markers, such as troponin I, creatine kinase-MB, lactate dehydrogenase and myoglobin. METHODS: We analyzed tumor necrosis factor-α -308 polymorphism in a total of 603 study participants: 293 elderly patients affected by acute myocardial infarction (STEMI and NSTEMI) and 310 healthy controls. RESULTS: We found that individuals carrying the tumor necrosis factor-α -308 AG+AA genotypes are significantly more represented among acute myocardial infarction patients affected by STEMI than among NSTEMI patients (OR=1.86, 95% CI 1.08-3.21, p=0.027) and healthy controls (OR=1.64, 95% CI 1.03-2.64, p=0.046). Furthermore, the patients carrying tumor necrosis factor-α -308 AG+AA genotypes displayed significant increased levels of biochemical myocardial ischemia markers. CONCLUSIONS: Our study shows a significant association between the tumor necrosis factor-α -308 polymorphism and the occurrence of STEMI, and suggests that the tumor necrosis factor-α -308 polymorphism could play a role in the pathogenesis of cardiac ischemic damage, AA+AG genotype carrier individuals being likely to be affected by more severe ischemic damage than the rest of the population.

Original languageEnglish
Pages (from-to)489-493
Number of pages5
JournalCoronary Artery Disease
Volume16
Issue number8
DOIs
Publication statusPublished - Dec 2005

Keywords

  • Acute myocardial infarction
  • Ischemia markers
  • ST-elevation myocardial infarction
  • Tumor necrosis factor-α polymorphism

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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