Tumor-nekrose-faktor alpha bei chronischer herzinsuffizienz. Klinische manifestation und therapeutische möglichkeiten

Translated title of the contribution: Tumor necrosis factor-alpha in chronic heart failure. Clinical manifestations and therapeutic options

Sabine Genth-Zotz, Aidan P. Bolger, Stefan D. Anker

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Chronic heart failure (CHF) may be seen as a multi-system disorder with its origin in the heart but including many extracardiac manifestations. Immunological abnormalities are recognized in this context, in particular, changes in the expression of mediators of the innate immune response. Importance of TNF: Higher levels of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF) are found in the circulation and in the myocardium of patients with chronic heart failure than in controls. TNF has been implicated in a number of pathophysiological processes that are thought to be important to the progression of chronic heart failure. Therapies directed against this cytokine might therefore represent anovel approach to heart failure management.

Original languageGerman
Pages (from-to)437-446
Number of pages10
JournalHerz
Volume26
Issue number7
Publication statusPublished - 2001

Fingerprint

Heart Failure
Tumor Necrosis Factor-alpha
Cytokines
Therapeutics
Innate Immunity
Myocardium

Keywords

  • Chronic heart failure
  • Tumor necrosis factor-alpha

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Tumor-nekrose-faktor alpha bei chronischer herzinsuffizienz. Klinische manifestation und therapeutische möglichkeiten. / Genth-Zotz, Sabine; Bolger, Aidan P.; Anker, Stefan D.

In: Herz, Vol. 26, No. 7, 2001, p. 437-446.

Research output: Contribution to journalArticle

Genth-Zotz, Sabine ; Bolger, Aidan P. ; Anker, Stefan D. / Tumor-nekrose-faktor alpha bei chronischer herzinsuffizienz. Klinische manifestation und therapeutische möglichkeiten. In: Herz. 2001 ; Vol. 26, No. 7. pp. 437-446.
@article{f34355794dee4cc58fc55e75903291ec,
title = "Tumor-nekrose-faktor alpha bei chronischer herzinsuffizienz. Klinische manifestation und therapeutische m{\"o}glichkeiten",
abstract = "Background: Chronic heart failure (CHF) may be seen as a multi-system disorder with its origin in the heart but including many extracardiac manifestations. Immunological abnormalities are recognized in this context, in particular, changes in the expression of mediators of the innate immune response. Importance of TNF: Higher levels of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF) are found in the circulation and in the myocardium of patients with chronic heart failure than in controls. TNF has been implicated in a number of pathophysiological processes that are thought to be important to the progression of chronic heart failure. Therapies directed against this cytokine might therefore represent anovel approach to heart failure management.",
keywords = "Chronic heart failure, Tumor necrosis factor-alpha",
author = "Sabine Genth-Zotz and Bolger, {Aidan P.} and Anker, {Stefan D.}",
year = "2001",
language = "Tedesco",
volume = "26",
pages = "437--446",
journal = "Herz",
issn = "0340-9937",
publisher = "Urban und Vogel",
number = "7",

}

TY - JOUR

T1 - Tumor-nekrose-faktor alpha bei chronischer herzinsuffizienz. Klinische manifestation und therapeutische möglichkeiten

AU - Genth-Zotz, Sabine

AU - Bolger, Aidan P.

AU - Anker, Stefan D.

PY - 2001

Y1 - 2001

N2 - Background: Chronic heart failure (CHF) may be seen as a multi-system disorder with its origin in the heart but including many extracardiac manifestations. Immunological abnormalities are recognized in this context, in particular, changes in the expression of mediators of the innate immune response. Importance of TNF: Higher levels of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF) are found in the circulation and in the myocardium of patients with chronic heart failure than in controls. TNF has been implicated in a number of pathophysiological processes that are thought to be important to the progression of chronic heart failure. Therapies directed against this cytokine might therefore represent anovel approach to heart failure management.

AB - Background: Chronic heart failure (CHF) may be seen as a multi-system disorder with its origin in the heart but including many extracardiac manifestations. Immunological abnormalities are recognized in this context, in particular, changes in the expression of mediators of the innate immune response. Importance of TNF: Higher levels of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF) are found in the circulation and in the myocardium of patients with chronic heart failure than in controls. TNF has been implicated in a number of pathophysiological processes that are thought to be important to the progression of chronic heart failure. Therapies directed against this cytokine might therefore represent anovel approach to heart failure management.

KW - Chronic heart failure

KW - Tumor necrosis factor-alpha

UR - http://www.scopus.com/inward/record.url?scp=0035187782&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035187782&partnerID=8YFLogxK

M3 - Articolo

C2 - 11765476

AN - SCOPUS:0035187782

VL - 26

SP - 437

EP - 446

JO - Herz

JF - Herz

SN - 0340-9937

IS - 7

ER -