Tumor necrosis factor alters synaptic transmission in rat hippocampal slices

Virginia Tancredi, Giovanna D'Arcangelo, Francesca Grassi, Paolo Tarroni, Gabriella Palmieri, Angela Santoni, Fabrizio Eusebi

Research output: Contribution to journalArticlepeer-review


The effects of human recombinant tumor necrosis factor (TNF-α) on the synaptic transmission were studied in rat hippocampal slices by using extracellular field potential recordings. Population spikes and/or excitatory postsynaptic potentials were extracellularly recorded in hippocampus CA1 region from stratum pyramidale and stratum radiatum, respectively, and synaptic transmission was examined in the Schaffer collateral/commissural-CA1 pathway. Basal neurotransmission slightly and promptly increased in slices acutely exposed to TNF-α (1-100 nM). Examination of the long-term potentiation (LTP) revealed that a brief treatment with the cytokine did not influence LTP, while a long-lasting application of TNF-α (50 min or more) inhibited LTP in a dose-dependent way in the range of 1-100 nM. A role for TNF-α as a peptide of immunological significance belonging to the family of brain neuromodulators is discussed.

Original languageEnglish
Pages (from-to)176-178
Number of pages3
JournalNeuroscience Letters
Issue number2
Publication statusPublished - Nov 9 1992


  • Hippocampus
  • Long-term potentiation
  • Neuromodulation
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Neuroscience(all)


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