TY - JOUR
T1 - Tumor necrosis factor alters synaptic transmission in rat hippocampal slices
AU - Tancredi, Virginia
AU - D'Arcangelo, Giovanna
AU - Grassi, Francesca
AU - Tarroni, Paolo
AU - Palmieri, Gabriella
AU - Santoni, Angela
AU - Eusebi, Fabrizio
PY - 1992/11/9
Y1 - 1992/11/9
N2 - The effects of human recombinant tumor necrosis factor (TNF-α) on the synaptic transmission were studied in rat hippocampal slices by using extracellular field potential recordings. Population spikes and/or excitatory postsynaptic potentials were extracellularly recorded in hippocampus CA1 region from stratum pyramidale and stratum radiatum, respectively, and synaptic transmission was examined in the Schaffer collateral/commissural-CA1 pathway. Basal neurotransmission slightly and promptly increased in slices acutely exposed to TNF-α (1-100 nM). Examination of the long-term potentiation (LTP) revealed that a brief treatment with the cytokine did not influence LTP, while a long-lasting application of TNF-α (50 min or more) inhibited LTP in a dose-dependent way in the range of 1-100 nM. A role for TNF-α as a peptide of immunological significance belonging to the family of brain neuromodulators is discussed.
AB - The effects of human recombinant tumor necrosis factor (TNF-α) on the synaptic transmission were studied in rat hippocampal slices by using extracellular field potential recordings. Population spikes and/or excitatory postsynaptic potentials were extracellularly recorded in hippocampus CA1 region from stratum pyramidale and stratum radiatum, respectively, and synaptic transmission was examined in the Schaffer collateral/commissural-CA1 pathway. Basal neurotransmission slightly and promptly increased in slices acutely exposed to TNF-α (1-100 nM). Examination of the long-term potentiation (LTP) revealed that a brief treatment with the cytokine did not influence LTP, while a long-lasting application of TNF-α (50 min or more) inhibited LTP in a dose-dependent way in the range of 1-100 nM. A role for TNF-α as a peptide of immunological significance belonging to the family of brain neuromodulators is discussed.
KW - Hippocampus
KW - Long-term potentiation
KW - Neuromodulation
KW - Tumor necrosis factor
UR - http://www.scopus.com/inward/record.url?scp=0026442657&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026442657&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(92)90071-E
DO - 10.1016/0304-3940(92)90071-E
M3 - Article
C2 - 1337194
AN - SCOPUS:0026442657
VL - 146
SP - 176
EP - 178
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 2
ER -