Seven ovarian and one cervical human cancer cell lines were examined for their sensitivity or resistance to tumor necrosis factor, to three topoisomerase II inhibitors and to cisplatin. Only one line exhibited the multidrug-resistance phenotype and another one an 'atypical'-MDR phenotype. The combination of TNF and topoisomerase-II inhibitors produced enhanced cytotoxicity and overcame the MDR and the atypical resistance. No potentiation of cisplatin cytotoxicity was observed. These findings suggest that TNF enhances the activity of DNA topoisomerase II both in TNF resistant and sensitive cells.
|Number of pages||7|
|Journal||International Journal of Oncology|
|Publication status||Published - 1995|
- ovarian cancer
- topoisomerase II
ASJC Scopus subject areas
- Cancer Research