Tumor necrosis factor microsatellite polymorphisms in Italian glioblastoma patients

S. Frigerio, E. Ciusani, A. Pozzi, A. Silvani, A. Salmaggi, A. Boiardi

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Tumor necrosis factor (TNF) genes map on the short arm of chromosome 6 and have been described to contain several polymorphic regions, the most informative of which are TNFα (13 alleles) and TNFb (8 alleles) microsatellites. We analyze TNFα and TNFb microsatellite polymorphisms in 58 Italian patients with glioblastoma (GBL) and 95 unrelated healthy controls. At the TNFb locus, we detected a statistically significant decrease in the TNFb4 allele in GBL patients compared with the controls (P = 0.002; P(corr) = 0.015). Among the patients, 8 were homozygous TNFb4 (+/+), 23 were TNFb4 heterozygous (+/-), and 27 were negative for TNFb4 (-/-). In a comparison with the controls, we detected a statistically significant difference (P = 0.017). In fact, although no difference was detected in +/-, statistically significant differences were detected both for an increase in -/- and for a decrease in +/+ in the patient groups (P = 0.006 and P = 0.047, respectively). These data suggest that TNFb4-negative individuals might preferentially develop a Th2-type immune response that could lead to a reduction in antitumor activity.

Original languageEnglish
Pages (from-to)172-174
Number of pages3
JournalCancer Genetics and Cytogenetics
Issue number2
Publication statusPublished - Mar 1999

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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