Tumor Necrosis Factor Related Apoptosis Inducing Ligand (Trail) in Endothelial Response to Biomechanical and Biochemical Stresses in Arteries

F. D'Auria, L. Centurione, Ma Centurione, A. Angelini, Roberta Di Pietro

Research output: Contribution to journalArticlepeer-review

Abstract

Shear stress is determined by three physical components described in a famous triad: blood flow, blood viscosity and vessel geometry. Through the direct action on endothelium, shear stress is able to radically interfere with endothelial properties and the physiology of the vascular wall. Endothelial cells (ECs) have also to sustain biochemical stresses represented by chemokines, growth factors, cytokines, complement, hormones, nitric oxide (NO), oxygen and reactive oxygen species (ROS). Many growth factors, cytokines, chemokines, hormones, and chemical substances, like NO, act and regulate endothelium functions and homeostasis. Among these cytokines Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) has been assigned a regulatory role in ECs physiology and physiopathology. Thus, the aim of this review is to provide a general overview of the endothelial response pathways after different types of biomechanical and biochemical stress in in vitro models and to analyze the crucial role of TRAIL under pathological conditions of the cardiocirculatory system like atherosclerosis, coronary artery disease, and diabetes. J. Cell. Biochem. 116: 2427-2434, 2015.

Original languageEnglish
Pages (from-to)2427-2434
Number of pages8
JournalJournal of Cellular Biochemistry
Volume116
Issue number11
DOIs
Publication statusPublished - Nov 1 2015

Keywords

  • CARDIOVASCULAR SYSTEM
  • ENDOTHELIAL CELLS
  • SHEAR STRESS
  • TRAIL
  • VASCULAR SMOOTH MUSCLE CELLS

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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