Abstract
Background: Tumor necrosis factor alpha (TNF-α) increases in patients with severe congestive heart failure (CHF) and cachexia. Two naturally occurring modulators of TNF-α activity have been identified in human serum. These two soluble proteins are the extracellular domains of the TNF receptors (sTNF-RI and sTNF-RII, respectively). The determination of circulating sTNF- Rs could provide us with some additional information about the activation of this cytokine in CHF. Methods and Results: This study was undertaken to examine the concentration of sTNF-Rs and of bioactive and antigenic TNF-α in 37 consecutive patients with various degrees of CHF compared with that of 26 age-matched healthy subjects. Antigenic TNF-α increased (from 14.3±7.08 to 33.5±13.1 pg/mL. P
| Original language | English |
|---|---|
| Pages (from-to) | 1479-1486 |
| Number of pages | 8 |
| Journal | Circulation |
| Volume | 92 |
| Issue number | 6 |
| Publication status | Published - 1995 |
Keywords
- heart failure
- hormones
- proteins
- receptors
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine