Tumor necrosis factor soluble receptors in patients with various degrees of congestive heart failure

R. Ferrari, T. Bachetti, R. Confortini, C. Opasich, O. Febo, A. Corti, G. Cassani, O. Visioli

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Tumor necrosis factor alpha (TNF-α) increases in patients with severe congestive heart failure (CHF) and cachexia. Two naturally occurring modulators of TNF-α activity have been identified in human serum. These two soluble proteins are the extracellular domains of the TNF receptors (sTNF-RI and sTNF-RII, respectively). The determination of circulating sTNF- Rs could provide us with some additional information about the activation of this cytokine in CHF. Methods and Results: This study was undertaken to examine the concentration of sTNF-Rs and of bioactive and antigenic TNF-α in 37 consecutive patients with various degrees of CHF compared with that of 26 age-matched healthy subjects. Antigenic TNF-α increased (from 14.3±7.08 to 33.5±13.1 pg/mL. P

Original languageEnglish
Pages (from-to)1479-1486
Number of pages8
JournalCirculation
Volume92
Issue number6
Publication statusPublished - 1995

Keywords

  • heart failure
  • hormones
  • proteins
  • receptors

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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