Tumor progression in human malignant melanoma is associated with changes in α6/β1 laminin receptor

P. G. Natali, M. R. Nicotra, R. Cavaliere, D. Giannarelli, A. Bigotti

Research output: Contribution to journalArticlepeer-review

Abstract

Cells of the melanocytic lineage have been shown to be capable of producing laminin and to lose this property during transformation. In the present study, we have evaluated immunohistochemically whether these change are paralleled by an altered expression of the α6/β1 laminin receptor. Results of this analysis have shown that while nevic cells display high levels of the receptor, this heterodimer undergoes a progressive decrease in expression in cutaneous melanomas of increasing invasiveness. A loss or unco-ordinated expression of the αl/β complex is present in the majority of the metastatic foci at different body sites. The present results show that during transformation the α6/βl laminin receptor undergoes quantitative alterations and deregulated expression of the 2 subunits. Although the functional relevance of these changes remains unknown, their occurrence in association with modifications of other cellular and extracellular macromolecules associated with tumor progression, strongly suggests a role in human melanoma progression.

Original languageEnglish
Pages (from-to)168-172
Number of pages5
JournalInternational Journal of Cancer
Volume49
Issue number2
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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