Tumor-released microvesicles as vehicles of immunosuppression

Roberta Valenti, Veronica Huber, Manuela Iero, Paola Filipazzi, Giorgio Parmiani, Licia Rivoltini

Research output: Contribution to journalArticle

273 Citations (Scopus)

Abstract

Tumor-released microvesicles, or exosomes, which are abundant in the body fluids of patients with cancer, are likely to be involved in tumor progression. We recently showed that microvesicles released by human melanoma and colorectal carcinoma cells can promote the differentiation of monocytes to myeloid-derived suppressor cells which support tumoral growth and immune escape. These findings underscore an important role for these extracellular organelles in remodeling tumor-stromal interactions to promote malignancy.

Original languageEnglish
Pages (from-to)2912-2915
Number of pages4
JournalCancer Research
Volume67
Issue number7
DOIs
Publication statusPublished - Apr 1 2007

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Immunosuppression
Neoplasms
Exosomes
Body Fluids
Organelles
Monocytes
Colorectal Neoplasms
Melanoma
Growth

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Tumor-released microvesicles as vehicles of immunosuppression. / Valenti, Roberta; Huber, Veronica; Iero, Manuela; Filipazzi, Paola; Parmiani, Giorgio; Rivoltini, Licia.

In: Cancer Research, Vol. 67, No. 7, 01.04.2007, p. 2912-2915.

Research output: Contribution to journalArticle

Valenti, Roberta ; Huber, Veronica ; Iero, Manuela ; Filipazzi, Paola ; Parmiani, Giorgio ; Rivoltini, Licia. / Tumor-released microvesicles as vehicles of immunosuppression. In: Cancer Research. 2007 ; Vol. 67, No. 7. pp. 2912-2915.
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