Abstract
Tumor-released microvesicles, or exosomes, which are abundant in the body fluids of patients with cancer, are likely to be involved in tumor progression. We recently showed that microvesicles released by human melanoma and colorectal carcinoma cells can promote the differentiation of monocytes to myeloid-derived suppressor cells which support tumoral growth and immune escape. These findings underscore an important role for these extracellular organelles in remodeling tumor-stromal interactions to promote malignancy.
| Original language | English |
|---|---|
| Pages (from-to) | 2912-2915 |
| Number of pages | 4 |
| Journal | Cancer Research |
| Volume | 67 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Apr 1 2007 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Tumor-released microvesicles as vehicles of immunosuppression. / Valenti, Roberta; Huber, Veronica; Iero, Manuela; Filipazzi, Paola; Parmiani, Giorgio; Rivoltini, Licia.
In: Cancer Research, Vol. 67, No. 7, 01.04.2007, p. 2912-2915.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tumor-released microvesicles as vehicles of immunosuppression
AU - Valenti, Roberta
AU - Huber, Veronica
AU - Iero, Manuela
AU - Filipazzi, Paola
AU - Parmiani, Giorgio
AU - Rivoltini, Licia
PY - 2007/4/1
Y1 - 2007/4/1
N2 - Tumor-released microvesicles, or exosomes, which are abundant in the body fluids of patients with cancer, are likely to be involved in tumor progression. We recently showed that microvesicles released by human melanoma and colorectal carcinoma cells can promote the differentiation of monocytes to myeloid-derived suppressor cells which support tumoral growth and immune escape. These findings underscore an important role for these extracellular organelles in remodeling tumor-stromal interactions to promote malignancy.
AB - Tumor-released microvesicles, or exosomes, which are abundant in the body fluids of patients with cancer, are likely to be involved in tumor progression. We recently showed that microvesicles released by human melanoma and colorectal carcinoma cells can promote the differentiation of monocytes to myeloid-derived suppressor cells which support tumoral growth and immune escape. These findings underscore an important role for these extracellular organelles in remodeling tumor-stromal interactions to promote malignancy.
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UR - http://www.scopus.com/inward/citedby.url?scp=34248216649&partnerID=8YFLogxK
U2 - 10.1158/0008-5472.CAN-07-0520
DO - 10.1158/0008-5472.CAN-07-0520
M3 - Article
VL - 67
SP - 2912
EP - 2915
JO - Journal of Cancer Research
JF - Journal of Cancer Research
SN - 0008-5472
IS - 7
ER -