Tumor size as a prognostic factor in patients with stage IIa colon cancer

Francesco Santullo, Alberto Biondi, Ferdinando C.M. Cananzi, Valeria Fico, Flavio Tirelli, Riccardo Ricci, Gianluca Rizzo, Claudio Coco, Claudio Mattana, Domenico D'Ugo, Roberto Persiani

Research output: Contribution to journalArticlepeer-review


Background The aim of this study was to identify stage II colon cancer patients with a high risk of recurrence. Methods All patients who underwent surgery for stage II colon cancer (CC) were retrospectively enrolled and sub-grouped according to TNM staging (IIa-b-c) and stage IIa in high (IIaHR) and low risk (IIaLR) according to pathologic features. The primary outcomes measured were the 5-year overall survival (OS) and disease-free survival (DFS). Results A total of 214 patients were reviewed. Only a maximum tumor diameter<4 cm in the IIaLR group was associated with a higher recurrence rate than a large tumor size (5-year DFS 71.7%vs.87.6%, p = 0.028). The DFS in the large IIaLR CC group was better than that in the IIaHR and IIb-c groups (5-year DFS: 92.7%vs.79.3%, p = 0.023). In contrast, the recurrence rate in the small IIaLR CC group was similar to that in the IIaHR, IIb-c stage CC group. Conclusions In stage IIa CC evaluation of the tumor size as a prognostic factor may help identify patients who could benefit from additional postoperative therapy.

Original languageEnglish
Pages (from-to)71-77
Number of pages7
JournalAmerican Journal of Surgery
Issue number1
Publication statusPublished - Jan 1 2018


  • Adiuvant treatment
  • Colorectal cancer
  • Prognosis
  • Stage II
  • Tumor size

ASJC Scopus subject areas

  • Surgery


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