Tumor size as a prognostic factor in patients with stage IIa colon cancer

Francesco Santullo, Alberto Biondi, Ferdinando C M Cananzi, Valeria Fico, Flavio Tirelli, Riccardo Ricci, Gianluca Rizzo, Claudio Coco, Claudio Mattana, Domenico D'Ugo, Roberto Persiani

Research output: Contribution to journalArticle

Abstract

BACKGROUND: The aim of this study was to identify stage II colon cancer patients with a high risk of recurrence.

METHODS: All patients who underwent surgery for stage II colon cancer (CC) were retrospectively enrolled and sub-grouped according to TNM staging (IIa-b-c) and stage IIa in high (IIaHR) and low risk (IIaLR) according to pathologic features. The primary outcomes measured were the 5-year overall survival (OS) and disease-free survival (DFS).

RESULTS: A total of 214 patients were reviewed. Only a maximum tumor diameter<4 cm in the IIaLR group was associated with a higher recurrence rate than a large tumor size (5-year DFS 71.7%vs.87.6%, p = 0.028). The DFS in the large IIaLR CC group was better than that in the IIaHR and IIb-c groups (5-year DFS: 92.7%vs.79.3%, p = 0.023). In contrast, the recurrence rate in the small IIaLR CC group was similar to that in the IIaHR, IIb-c stage CC group.

CONCLUSIONS: In stage IIa CC evaluation of the tumor size as a prognostic factor may help identify patients who could benefit from additional postoperative therapy.

Original languageEnglish
Pages (from-to)71-77
Number of pages7
JournalAmerican Journal of Surgery
Volume215
Issue number1
DOIs
Publication statusPublished - Jan 2018

Fingerprint

Colonic Neoplasms
Disease-Free Survival
Neoplasms
Recurrence
Neoplasm Staging
Survival

Keywords

  • Adenocarcinoma/diagnosis
  • Adult
  • Aged
  • Aged, 80 and over
  • Colectomy
  • Colonic Neoplasms/diagnosis
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local/epidemiology
  • Neoplasm Staging
  • Prognosis
  • Retrospective Studies
  • Survival Analysis
  • Tumor Burden

Cite this

Tumor size as a prognostic factor in patients with stage IIa colon cancer. / Santullo, Francesco; Biondi, Alberto; Cananzi, Ferdinando C M; Fico, Valeria; Tirelli, Flavio; Ricci, Riccardo; Rizzo, Gianluca; Coco, Claudio; Mattana, Claudio; D'Ugo, Domenico; Persiani, Roberto.

In: American Journal of Surgery, Vol. 215, No. 1, 01.2018, p. 71-77.

Research output: Contribution to journalArticle

Santullo, F, Biondi, A, Cananzi, FCM, Fico, V, Tirelli, F, Ricci, R, Rizzo, G, Coco, C, Mattana, C, D'Ugo, D & Persiani, R 2018, 'Tumor size as a prognostic factor in patients with stage IIa colon cancer', American Journal of Surgery, vol. 215, no. 1, pp. 71-77. https://doi.org/10.1016/j.amjsurg.2017.03.038
Santullo, Francesco ; Biondi, Alberto ; Cananzi, Ferdinando C M ; Fico, Valeria ; Tirelli, Flavio ; Ricci, Riccardo ; Rizzo, Gianluca ; Coco, Claudio ; Mattana, Claudio ; D'Ugo, Domenico ; Persiani, Roberto. / Tumor size as a prognostic factor in patients with stage IIa colon cancer. In: American Journal of Surgery. 2018 ; Vol. 215, No. 1. pp. 71-77.
@article{f01311898b3a4111b76b4c5655552b6b,
title = "Tumor size as a prognostic factor in patients with stage IIa colon cancer",
abstract = "BACKGROUND: The aim of this study was to identify stage II colon cancer patients with a high risk of recurrence.METHODS: All patients who underwent surgery for stage II colon cancer (CC) were retrospectively enrolled and sub-grouped according to TNM staging (IIa-b-c) and stage IIa in high (IIaHR) and low risk (IIaLR) according to pathologic features. The primary outcomes measured were the 5-year overall survival (OS) and disease-free survival (DFS).RESULTS: A total of 214 patients were reviewed. Only a maximum tumor diameter<4 cm in the IIaLR group was associated with a higher recurrence rate than a large tumor size (5-year DFS 71.7{\%}vs.87.6{\%}, p = 0.028). The DFS in the large IIaLR CC group was better than that in the IIaHR and IIb-c groups (5-year DFS: 92.7{\%}vs.79.3{\%}, p = 0.023). In contrast, the recurrence rate in the small IIaLR CC group was similar to that in the IIaHR, IIb-c stage CC group.CONCLUSIONS: In stage IIa CC evaluation of the tumor size as a prognostic factor may help identify patients who could benefit from additional postoperative therapy.",
keywords = "Adenocarcinoma/diagnosis, Adult, Aged, Aged, 80 and over, Colectomy, Colonic Neoplasms/diagnosis, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neoplasm Recurrence, Local/epidemiology, Neoplasm Staging, Prognosis, Retrospective Studies, Survival Analysis, Tumor Burden",
author = "Francesco Santullo and Alberto Biondi and Cananzi, {Ferdinando C M} and Valeria Fico and Flavio Tirelli and Riccardo Ricci and Gianluca Rizzo and Claudio Coco and Claudio Mattana and Domenico D'Ugo and Roberto Persiani",
note = "Copyright {\circledC} 2017 Elsevier Inc. All rights reserved.",
year = "2018",
month = "1",
doi = "10.1016/j.amjsurg.2017.03.038",
language = "English",
volume = "215",
pages = "71--77",
journal = "American Journal of Surgery",
issn = "0002-9610",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Tumor size as a prognostic factor in patients with stage IIa colon cancer

AU - Santullo, Francesco

AU - Biondi, Alberto

AU - Cananzi, Ferdinando C M

AU - Fico, Valeria

AU - Tirelli, Flavio

AU - Ricci, Riccardo

AU - Rizzo, Gianluca

AU - Coco, Claudio

AU - Mattana, Claudio

AU - D'Ugo, Domenico

AU - Persiani, Roberto

N1 - Copyright © 2017 Elsevier Inc. All rights reserved.

PY - 2018/1

Y1 - 2018/1

N2 - BACKGROUND: The aim of this study was to identify stage II colon cancer patients with a high risk of recurrence.METHODS: All patients who underwent surgery for stage II colon cancer (CC) were retrospectively enrolled and sub-grouped according to TNM staging (IIa-b-c) and stage IIa in high (IIaHR) and low risk (IIaLR) according to pathologic features. The primary outcomes measured were the 5-year overall survival (OS) and disease-free survival (DFS).RESULTS: A total of 214 patients were reviewed. Only a maximum tumor diameter<4 cm in the IIaLR group was associated with a higher recurrence rate than a large tumor size (5-year DFS 71.7%vs.87.6%, p = 0.028). The DFS in the large IIaLR CC group was better than that in the IIaHR and IIb-c groups (5-year DFS: 92.7%vs.79.3%, p = 0.023). In contrast, the recurrence rate in the small IIaLR CC group was similar to that in the IIaHR, IIb-c stage CC group.CONCLUSIONS: In stage IIa CC evaluation of the tumor size as a prognostic factor may help identify patients who could benefit from additional postoperative therapy.

AB - BACKGROUND: The aim of this study was to identify stage II colon cancer patients with a high risk of recurrence.METHODS: All patients who underwent surgery for stage II colon cancer (CC) were retrospectively enrolled and sub-grouped according to TNM staging (IIa-b-c) and stage IIa in high (IIaHR) and low risk (IIaLR) according to pathologic features. The primary outcomes measured were the 5-year overall survival (OS) and disease-free survival (DFS).RESULTS: A total of 214 patients were reviewed. Only a maximum tumor diameter<4 cm in the IIaLR group was associated with a higher recurrence rate than a large tumor size (5-year DFS 71.7%vs.87.6%, p = 0.028). The DFS in the large IIaLR CC group was better than that in the IIaHR and IIb-c groups (5-year DFS: 92.7%vs.79.3%, p = 0.023). In contrast, the recurrence rate in the small IIaLR CC group was similar to that in the IIaHR, IIb-c stage CC group.CONCLUSIONS: In stage IIa CC evaluation of the tumor size as a prognostic factor may help identify patients who could benefit from additional postoperative therapy.

KW - Adenocarcinoma/diagnosis

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Colectomy

KW - Colonic Neoplasms/diagnosis

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Middle Aged

KW - Neoplasm Recurrence, Local/epidemiology

KW - Neoplasm Staging

KW - Prognosis

KW - Retrospective Studies

KW - Survival Analysis

KW - Tumor Burden

U2 - 10.1016/j.amjsurg.2017.03.038

DO - 10.1016/j.amjsurg.2017.03.038

M3 - Article

C2 - 28410630

VL - 215

SP - 71

EP - 77

JO - American Journal of Surgery

JF - American Journal of Surgery

SN - 0002-9610

IS - 1

ER -