Tumor Size is a Determinant of the Rate of Stage T1 Renal Cell Cancer Synchronous Metastasis

Giovanni Lughezzani, Claudio Jeldres, Hendrik Isbarn, Paul Perrotte, Shahrokh F. Shariat, Maxine Sun, Hugues Widmer, Philippe Arjane, Francois Peloquin, Daniel Pharand, Jean Jacques Patard, Markus Graefen, Francesco Montorsi, Pierre I. Karakiewicz

Research output: Contribution to journalArticlepeer-review


Purpose: A recent multi-institutional analysis of 995 patients treated for renal cell cancer questioned the relationship between tumor size and the synchronous metastasis rate. We revisited the hypothesis that metastatic potential is unrelated to tumor size. Materials and Methods: We tested the relationship between tumor size and synchronous metastasis in 22,204 patients with T1a and T1b renal cell cancer diagnosed and/or treated with nephrectomy for clear cell, papillary or chromophobe histological subtypes in 1 of 9 Surveillance, Epidemiology and End Results registries between 1988 and 2004. Results: In the study population the synchronous metastasis rate was 9.6%, including 5.6% vs 14.2% for T1a vs T1b. Stratification by 1 cm tumor size intervals revealed that the rate increased with increasing tumor size, that is 4.8% at 1.0 cm or less, 4.2% at 1.1 to 2.0 cm, 4.9% at 2.1 to 3.0 cm, 7.1% at 3.1 to 4.0 cm, 12.1% at 4.1 to 5.0 cm, 13.3% at 5.1 to 6.0 cm and 18.4% 6.1 to 7.0 cm (chi-square trend p

Original languageEnglish
Pages (from-to)1287-1293
Number of pages7
JournalJournal of Urology
Issue number4 SUPPL.
Publication statusPublished - Oct 2009


  • carcinoma
  • kidney
  • neoplasm metastasis
  • neoplasm staging
  • nephrectomy
  • renal cell

ASJC Scopus subject areas

  • Urology


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