TY - JOUR
T1 - Tumor Size is a Determinant of the Rate of Stage T1 Renal Cell Cancer Synchronous Metastasis
AU - Lughezzani, Giovanni
AU - Jeldres, Claudio
AU - Isbarn, Hendrik
AU - Perrotte, Paul
AU - Shariat, Shahrokh F.
AU - Sun, Maxine
AU - Widmer, Hugues
AU - Arjane, Philippe
AU - Peloquin, Francois
AU - Pharand, Daniel
AU - Patard, Jean Jacques
AU - Graefen, Markus
AU - Montorsi, Francesco
AU - Karakiewicz, Pierre I.
PY - 2009/10
Y1 - 2009/10
N2 - Purpose: A recent multi-institutional analysis of 995 patients treated for renal cell cancer questioned the relationship between tumor size and the synchronous metastasis rate. We revisited the hypothesis that metastatic potential is unrelated to tumor size. Materials and Methods: We tested the relationship between tumor size and synchronous metastasis in 22,204 patients with T1a and T1b renal cell cancer diagnosed and/or treated with nephrectomy for clear cell, papillary or chromophobe histological subtypes in 1 of 9 Surveillance, Epidemiology and End Results registries between 1988 and 2004. Results: In the study population the synchronous metastasis rate was 9.6%, including 5.6% vs 14.2% for T1a vs T1b. Stratification by 1 cm tumor size intervals revealed that the rate increased with increasing tumor size, that is 4.8% at 1.0 cm or less, 4.2% at 1.1 to 2.0 cm, 4.9% at 2.1 to 3.0 cm, 7.1% at 3.1 to 4.0 cm, 12.1% at 4.1 to 5.0 cm, 13.3% at 5.1 to 6.0 cm and 18.4% 6.1 to 7.0 cm (chi-square trend p
AB - Purpose: A recent multi-institutional analysis of 995 patients treated for renal cell cancer questioned the relationship between tumor size and the synchronous metastasis rate. We revisited the hypothesis that metastatic potential is unrelated to tumor size. Materials and Methods: We tested the relationship between tumor size and synchronous metastasis in 22,204 patients with T1a and T1b renal cell cancer diagnosed and/or treated with nephrectomy for clear cell, papillary or chromophobe histological subtypes in 1 of 9 Surveillance, Epidemiology and End Results registries between 1988 and 2004. Results: In the study population the synchronous metastasis rate was 9.6%, including 5.6% vs 14.2% for T1a vs T1b. Stratification by 1 cm tumor size intervals revealed that the rate increased with increasing tumor size, that is 4.8% at 1.0 cm or less, 4.2% at 1.1 to 2.0 cm, 4.9% at 2.1 to 3.0 cm, 7.1% at 3.1 to 4.0 cm, 12.1% at 4.1 to 5.0 cm, 13.3% at 5.1 to 6.0 cm and 18.4% 6.1 to 7.0 cm (chi-square trend p
KW - carcinoma
KW - kidney
KW - neoplasm metastasis
KW - neoplasm staging
KW - nephrectomy
KW - renal cell
UR - http://www.scopus.com/inward/record.url?scp=69749088758&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=69749088758&partnerID=8YFLogxK
U2 - 10.1016/j.juro.2009.06.018
DO - 10.1016/j.juro.2009.06.018
M3 - Article
C2 - 19683281
AN - SCOPUS:69749088758
VL - 182
SP - 1287
EP - 1293
JO - Journal of Urology
JF - Journal of Urology
SN - 0022-5347
IS - 4 SUPPL.
ER -