Tumor suppression by DNA base excision repair

Research output: Contribution to journalArticlepeer-review

Abstract

Base excision repair (BER) is the main pathway for repair of endogenous DNA damage. It was expected that different tumor types could derive from BER defects but to date this link is elusive. In vitro and molecular epidemiology studies may be used to unravel this issue.

Original languageEnglish
Pages (from-to)727-743
Number of pages17
JournalMini-Reviews in Medicinal Chemistry
Volume7
Issue number7
DOIs
Publication statusPublished - Jul 2007

Keywords

  • 8-oxoguanine
  • Chemotherapy
  • DNA base excision repair
  • Glycosylase
  • In vitro neoplastic transformation
  • Molecular epidemiology
  • Mutation
  • Oxidative DNA damage

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Chemistry(all)
  • Pharmacology

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