Abstract
Base excision repair (BER) is the main pathway for repair of endogenous DNA damage. It was expected that different tumor types could derive from BER defects but to date this link is elusive. In vitro and molecular epidemiology studies may be used to unravel this issue.
| Original language | English |
|---|---|
| Pages (from-to) | 727-743 |
| Number of pages | 17 |
| Journal | Mini-Reviews in Medicinal Chemistry |
| Volume | 7 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 2007 |
Keywords
- 8-oxoguanine
- Chemotherapy
- DNA base excision repair
- Glycosylase
- In vitro neoplastic transformation
- Molecular epidemiology
- Mutation
- Oxidative DNA damage
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Chemistry(all)
- Pharmacology