TY - JOUR
T1 - Tumor suppressor microRNAs
T2 - A novel non-coding alliance against cancer
AU - Blandino, Giovanni
AU - Fazi, Francesco
AU - Donzelli, Sara
AU - Kedmi, Merav
AU - Sas-Chen, Aldema
AU - Muti, Paola
AU - Strano, Sabrina
AU - Yarden, Yosef
PY - 2014/8/19
Y1 - 2014/8/19
N2 - Tumor initiation and progression are the outcomes of a stepwise accumulation of genetic alterations. Among these, gene amplification and aberrant expression of oncogenic proteins, as well as deletion or inactivation of tumor suppressor genes, represent hallmark steps. Mounting evidence collected over the last few years has identified different populations of non-coding RNAs as major players in tumor suppression in almost all cancer types. Elucidating the diverse molecular mechanisms underlying the roles of non-coding RNAs in tumor progression might provide illuminating insights, potentially able to assist improved diagnosis, better staging and effective treatments of human cancers. Here we focus on several groups of tumor suppressor microRNAs, whose downregulation exerts a profound oncologic impact and might be harnessed for the benefit of cancer patients.
AB - Tumor initiation and progression are the outcomes of a stepwise accumulation of genetic alterations. Among these, gene amplification and aberrant expression of oncogenic proteins, as well as deletion or inactivation of tumor suppressor genes, represent hallmark steps. Mounting evidence collected over the last few years has identified different populations of non-coding RNAs as major players in tumor suppression in almost all cancer types. Elucidating the diverse molecular mechanisms underlying the roles of non-coding RNAs in tumor progression might provide illuminating insights, potentially able to assist improved diagnosis, better staging and effective treatments of human cancers. Here we focus on several groups of tumor suppressor microRNAs, whose downregulation exerts a profound oncologic impact and might be harnessed for the benefit of cancer patients.
KW - Cancer
KW - Tumor suppressor microRNAs
UR - http://www.scopus.com/inward/record.url?scp=84905108333&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84905108333&partnerID=8YFLogxK
U2 - 10.1016/j.febslet.2014.03.033
DO - 10.1016/j.febslet.2014.03.033
M3 - Article
C2 - 24681102
AN - SCOPUS:84905108333
VL - 588
SP - 2639
EP - 2652
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 16
ER -