TUMOR SUPPRESSOR p63 REGULATES EXPRESSION OF UBIQUITIN LIGASE Pirh2

A. A. Daks, A. V. Petukhov, O. Yu Shuvalov, E. A. Vasilieva, G. Melino, N. A. Barlev, O. A. Fedorova

Research output: Contribution to journalArticlepeer-review

Abstract

Transcription factor p63 is a member of the p53 protein family. Due to the high degree of structural similarity p53, p63, and p73 are known to have overlapping functions relating to cell cycle regulation, apoptosis and tumor transformation. Furthermore, p63 plays crucial role in epidermal tissue development and differentiation. Pirh2 (product of RCHY1 gene) is an E3 ubiquitin ligase modifying all three members of the p53 family resulting in their subsequent proteasomal degradation. Our results demonstrate that p63, similar to p53, is able to regulate expression levels of Pirh2. Importantly, Pirh2 expression is activated only by transcriptionally active isoform of p63--TAp63, but not the N-terminally truncated ΔNp63.

Original languageEnglish
Pages (from-to)876-879
Number of pages4
JournalTsitologiia
Volume57
Issue number12
Publication statusPublished - 2015

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medicine(all)
  • Histology

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