Tumor-targeting vaccination instructs graft-vs.-tumor immune responses

Teresa Manzo, Rodrigo Hess Michelini, Tabea Sturmheit, Veronica Basso, Matteo Bellone, Anna Mondino

Research output: Contribution to journalArticlepeer-review

Abstract

Anticancer vaccines hold the potential to promote tumor eradication by immune effector cells. We have recently found dendritic cell-based vaccines to instruct graft-vs.-tumor responses following allogeneic hematopoietic stem cell transplantation and donor lymphocyte infusion. Vaccination was essential to elicit the intratumoral expression of interferon , promote local inflammation, and stimulate therapeutic T-cell infiltration

Original languageEnglish
Article numbere25996
JournalOncoImmunology
Volume2
Issue number10
DOIs
Publication statusPublished - 2013

Keywords

  • Immunotherapy
  • Minor histocompatibility antigens
  • T cells
  • Transplantation
  • Tumor
  • Vaccination

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

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