Tumor vasculature targeting through NGR peptide-based drugdelivery systems

Research output: Contribution to journalArticle

Abstract

Various peptide sequences have been discovered by selecting peptide-phage display libraries in vitro againstspecific receptors or in vivo in tumor-bearing animals. One class of these peptides is characterized by the presence of Asn-Gly-Asp (NGR), a structural motif that can recognize the endothelium and other cells of neoangiogenic vessels. Becauseof this property these peptides have been used by several investigators to deliver a variety of drugs, cytokines, nanoparticles,viruses and imaging agents to tumor blood vessels. Here we review the reports on these conjugates and discuss thestructural, functional and stability properties of NGR embedded into different molecular scaffolds.

Original languageEnglish
Pages (from-to)1128-1134
Number of pages7
JournalCurrent Pharmaceutical Biotechnology
Volume12
Issue number8
DOIs
Publication statusPublished - Aug 2011

Keywords

  • αvβ3 integrin
  • Angiogenesis
  • Asparaginedeamidation
  • CD13
  • Isoaspartate
  • IsoDGR
  • NGR motif
  • NGR-TNF
  • Peptide-phage display library
  • Vascular targeting

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Biotechnology

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