Tumoral CD105 is a novel independent prognostic marker for prognosis in clear-cell renal cell carcinoma

A. Saroufim; Y. Messai; M. Hasmim; N. Rioux; R. Iacovelli; G. Verhoest; K. Bensalah; J. J. Patard; L. Albiges; B. Azzarone; B. Escudier; S. Chouaib

doi:10.1038/bjc.2014.71

Tumoral CD105 is a novel independent prognostic marker for prognosis in clear-cell renal cell carcinoma

A. Saroufim, Y. Messai, M. Hasmim, N. Rioux, R. Iacovelli, G. Verhoest, K. Bensalah, J. J. Patard, L. Albiges, B. Azzarone, B. Escudier, S. Chouaib

Research output: Contribution to journal › Article › peer-review

Abstract

Background:Angiogenesis is essential for tumour growth and metastasis. There are conflicting reports as to whether microvessel density (MVD) using the endothelial marker CD105 (cluster of differentiation molecule 105) in clear-cell renal cell carcinomas (ccRCC) is associated with prognosis. Recently, CD105 has been described as a RCC cancer stem cell marker.Methods:A total of 102 ccRCC were analysed. Representative tumour sections were stained for CD105. Vascularity (endothelial CD105) was quantified by MVD. The immunohistochemistry analysis detected positive (if present) or negative (if absent) CD105 tumoral staining. This retrospective population-based study was evaluated using Kaplan-Meier method, t-test and Cox proportional hazard model.Results:We found that the expression of endothelial CD105 (MVD) negatively correlated with nuclear grade (P

Original language	English
Pages (from-to)	1778-1784
Number of pages	7
Journal	British Journal of Cancer
Volume	110
Issue number	7
DOIs	https://doi.org/10.1038/bjc.2014.71
Publication status	Published - Apr 1 2014

Keywords

ccRCC
CD105
endothelial
prognosis
tumoral

ASJC Scopus subject areas

Cancer Research
Oncology

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10.1038/bjc.2014.71

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Tumoral CD105 is a novel independent prognostic marker for prognosis in clear-cell renal cell carcinoma. / Saroufim, A.; Messai, Y.; Hasmim, M.; Rioux, N.; Iacovelli, R.; Verhoest, G.; Bensalah, K.; Patard, J. J.; Albiges, L.; Azzarone, B.; Escudier, B.; Chouaib, S.

In: British Journal of Cancer, Vol. 110, No. 7, 01.04.2014, p. 1778-1784.

Research output: Contribution to journal › Article › peer-review

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abstract = "Background:Angiogenesis is essential for tumour growth and metastasis. There are conflicting reports as to whether microvessel density (MVD) using the endothelial marker CD105 (cluster of differentiation molecule 105) in clear-cell renal cell carcinomas (ccRCC) is associated with prognosis. Recently, CD105 has been described as a RCC cancer stem cell marker.Methods:A total of 102 ccRCC were analysed. Representative tumour sections were stained for CD105. Vascularity (endothelial CD105) was quantified by MVD. The immunohistochemistry analysis detected positive (if present) or negative (if absent) CD105 tumoral staining. This retrospective population-based study was evaluated using Kaplan-Meier method, t-test and Cox proportional hazard model.Results:We found that the expression of endothelial CD105 (MVD) negatively correlated with nuclear grade (P",

keywords = "ccRCC, CD105, endothelial, prognosis, tumoral",

author = "A. Saroufim and Y. Messai and M. Hasmim and N. Rioux and R. Iacovelli and G. Verhoest and K. Bensalah and Patard, {J. J.} and L. Albiges and B. Azzarone and B. Escudier and S. Chouaib",

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AU - Messai, Y.

AU - Hasmim, M.

AU - Rioux, N.

AU - Iacovelli, R.

AU - Verhoest, G.

AU - Bensalah, K.

AU - Patard, J. J.

AU - Albiges, L.

AU - Azzarone, B.

AU - Escudier, B.

AU - Chouaib, S.

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Tumoral CD105 is a novel independent prognostic marker for prognosis in clear-cell renal cell carcinoma

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Keywords

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