Abstract
Tumorigenic and metastatic potential were studied in relation to class I MHC expression in four different SV40-transformed BALB/c cell lines. All the lines studied, tumorigenic or not, expressed both H-2K(d) and D(d), so MHC antigens did not seem to be involved in the control of SV40-transformed cells' growth in vivo. Lung metastases were observed in all tumour-bearing mice. Cells cultured after in vivo passage, obtained either from tumour tissue or from individual lung metastases, still expressed similar levels of H-2(d) antigens, thus suggesting that tumour growth and metastasis do not occur through the selection of variants with altered MHC expression.
Original language | English |
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Pages (from-to) | 45-51 |
Number of pages | 7 |
Journal | Journal of Immunogenetics |
Volume | 16 |
Issue number | 1 |
Publication status | Published - 1989 |
ASJC Scopus subject areas
- Genetics
- Immunology