Tumorigenic and metastatic potential were studied in relation to class I MHC expression in four different SV40-transformed BALB/c cell lines. All the lines studied, tumorigenic or not, expressed both H-2K(d) and D(d), so MHC antigens did not seem to be involved in the control of SV40-transformed cells' growth in vivo. Lung metastases were observed in all tumour-bearing mice. Cells cultured after in vivo passage, obtained either from tumour tissue or from individual lung metastases, still expressed similar levels of H-2(d) antigens, thus suggesting that tumour growth and metastasis do not occur through the selection of variants with altered MHC expression.
|Number of pages||7|
|Journal||Journal of Immunogenetics|
|Publication status||Published - 1989|
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