Tumorigenic and metastatic ability of SV40-transformed BALB/c cell lines and MHC antigen expression

C. De Giovanni, G. Nicoletti, B. Del Re, K. Scotlandi, G. Prodi, P. L. Lollini, P. Nanni

Research output: Contribution to journalArticlepeer-review

Abstract

Tumorigenic and metastatic potential were studied in relation to class I MHC expression in four different SV40-transformed BALB/c cell lines. All the lines studied, tumorigenic or not, expressed both H-2K(d) and D(d), so MHC antigens did not seem to be involved in the control of SV40-transformed cells' growth in vivo. Lung metastases were observed in all tumour-bearing mice. Cells cultured after in vivo passage, obtained either from tumour tissue or from individual lung metastases, still expressed similar levels of H-2(d) antigens, thus suggesting that tumour growth and metastasis do not occur through the selection of variants with altered MHC expression.

Original languageEnglish
Pages (from-to)45-51
Number of pages7
JournalJournal of Immunogenetics
Volume16
Issue number1
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Genetics
  • Immunology

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