Tumorigenic and metastatic activity of human thyroid cancer stem cells

Matilde Todaro, Flora Iovino, Vincenzo Eterno, Patrizia Cammareri, Guido Gambara, Virginia Espina, Gaspare Gulotta, Francesco Dieli, Silvia Giordano, Ruggero De Maria, Giorgio Stassi

Research output: Contribution to journalArticle

Abstract

Thyroid carcinoma is the most common endocrine malignancy and the first cause of death among endocrine cancers. We show that the tumorigenic capacity in thyroid cancer is confined in a small subpopulation of stem-like cells with high aldehyde dehydrogenase (ALDHhigh) activity and unlimited replication potential. ALDHhigh cells can be expanded indefinitely in vitro as tumor spheres, which retain the tumorigenic potential upon delivery in immunocompromised mice. Orthotopic injection of minute numbers of thyroid cancer stem cells recapitulates the behavior of the parental tumor, including the aggressive metastatic features of undifferentiated thyroid carcinomas, which are sustained by constitutive activation of cMet and Akt in thyroid cancer stem cells. The identification of tumorigenic and metastagenic thyroid cancer cells may provide unprecedented preclinical tools for development and preclinical validation of novel targeted therapies.

Original languageEnglish
Pages (from-to)8874-8885
Number of pages12
JournalCancer Research
Volume70
Issue number21
DOIs
Publication statusPublished - Nov 1 2010

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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  • Cite this

    Todaro, M., Iovino, F., Eterno, V., Cammareri, P., Gambara, G., Espina, V., Gulotta, G., Dieli, F., Giordano, S., De Maria, R., & Stassi, G. (2010). Tumorigenic and metastatic activity of human thyroid cancer stem cells. Cancer Research, 70(21), 8874-8885. https://doi.org/10.1158/0008-5472.CAN-10-1994