Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: Potential targets of anti-cancer therapy

Research output: Contribution to journalArticlepeer-review

Abstract

Tumour-associated macrophages (TAM) represent the major inflammatory component of the stroma of many tumours, and can affect different aspects of the neoplastic tissue. Many observations indicate that TAM express several M2-associated pro-tumoural functions, including promotion of angiogenesis, matrix remodelling and suppression of adaptive immunity. The pro-tumoural role of TAM in cancer is further supported by clinical studies that found a correlation between the high macrophage content of tumours and poor patient prognosis. Evidence is presented here supporting the view that TAM represent a unique and distinct M2-skewed myeloid population and are a potential target for anti-cancer therapy.

Original languageEnglish
Pages (from-to)717-727
Number of pages11
JournalEuropean Journal of Cancer
Volume42
Issue number6
DOIs
Publication statusPublished - Apr 2006

Keywords

  • Cancer
  • Inflammation
  • TAM

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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