11 Citations (Scopus)

Abstract

High levels of serum carcinoembryonic antigen (S-CEA) are considered a negative prognostic factor in non-small-cell lung cancer (NSCLC), while the prognostic value of tumour CEA (T-CEA) is unknown. We investigated the prognostic role of T-CEA in radically resected early stage NSCLC. We measured preoperative S-CEA levels and T-CEA in 146 patients with stage 1-2 NSCLC, and analysed their influence on survival. In patients positive for T-CEA, 3-year survival was 80%, compared to 65% in T-CEA-negative patients (p = 0.03). After stratification by histology, T-CEA positivity was prognostic of better survival in squamous cell carcinoma (SCC) (p = 0.024) but not in adenocarcinomas (ADK) (p = 0.87). Multiple Cox regression analysis showed that T-CEA positivity was an independent predictor of better survival in patients with early stage NSCLC (p = 0.02). In SCC patients, the magnitude of the hazard ratio was confirmed even if the precision of the estimate is decreased (p = 0.06). In conclusion, T-CEA expression appears to be an important prognostic factor in early stage SSC of the lung.

Original languageEnglish
Pages (from-to)233-240
Number of pages8
JournalLung Cancer
Volume48
Issue number2
DOIs
Publication statusPublished - May 2005

Fingerprint

Squamous Cell Carcinoma
Lung
Non-Small Cell Lung Carcinoma
Neoplasms
Survival
Carcinoembryonic Antigen
Serum
Histology
Adenocarcinoma
Regression Analysis

Keywords

  • CEA
  • Lung cancer
  • Prognostic factors
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Oncology

Cite this

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title = "Tumour CEA as predictor of better outcome in squamous cell carcinoma of the lung",
abstract = "High levels of serum carcinoembryonic antigen (S-CEA) are considered a negative prognostic factor in non-small-cell lung cancer (NSCLC), while the prognostic value of tumour CEA (T-CEA) is unknown. We investigated the prognostic role of T-CEA in radically resected early stage NSCLC. We measured preoperative S-CEA levels and T-CEA in 146 patients with stage 1-2 NSCLC, and analysed their influence on survival. In patients positive for T-CEA, 3-year survival was 80{\%}, compared to 65{\%} in T-CEA-negative patients (p = 0.03). After stratification by histology, T-CEA positivity was prognostic of better survival in squamous cell carcinoma (SCC) (p = 0.024) but not in adenocarcinomas (ADK) (p = 0.87). Multiple Cox regression analysis showed that T-CEA positivity was an independent predictor of better survival in patients with early stage NSCLC (p = 0.02). In SCC patients, the magnitude of the hazard ratio was confirmed even if the precision of the estimate is decreased (p = 0.06). In conclusion, T-CEA expression appears to be an important prognostic factor in early stage SSC of the lung.",
keywords = "CEA, Lung cancer, Prognostic factors, Squamous cell carcinoma",
author = "Giulia Veronesi and Giuseppe Pelosi and Angelica Sonzogni and Leon, {Maria Elena} and Massimiliano D'Aiuto and Roberto Gasparri and {De Braud}, Filippo and {De Pas}, Tommaso and Maria Sandri and Lorenzo Spaggiari",
year = "2005",
month = "5",
doi = "10.1016/j.lungcan.2004.10.018",
language = "English",
volume = "48",
pages = "233--240",
journal = "Lung Cancer",
issn = "0169-5002",
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TY - JOUR

T1 - Tumour CEA as predictor of better outcome in squamous cell carcinoma of the lung

AU - Veronesi, Giulia

AU - Pelosi, Giuseppe

AU - Sonzogni, Angelica

AU - Leon, Maria Elena

AU - D'Aiuto, Massimiliano

AU - Gasparri, Roberto

AU - De Braud, Filippo

AU - De Pas, Tommaso

AU - Sandri, Maria

AU - Spaggiari, Lorenzo

PY - 2005/5

Y1 - 2005/5

N2 - High levels of serum carcinoembryonic antigen (S-CEA) are considered a negative prognostic factor in non-small-cell lung cancer (NSCLC), while the prognostic value of tumour CEA (T-CEA) is unknown. We investigated the prognostic role of T-CEA in radically resected early stage NSCLC. We measured preoperative S-CEA levels and T-CEA in 146 patients with stage 1-2 NSCLC, and analysed their influence on survival. In patients positive for T-CEA, 3-year survival was 80%, compared to 65% in T-CEA-negative patients (p = 0.03). After stratification by histology, T-CEA positivity was prognostic of better survival in squamous cell carcinoma (SCC) (p = 0.024) but not in adenocarcinomas (ADK) (p = 0.87). Multiple Cox regression analysis showed that T-CEA positivity was an independent predictor of better survival in patients with early stage NSCLC (p = 0.02). In SCC patients, the magnitude of the hazard ratio was confirmed even if the precision of the estimate is decreased (p = 0.06). In conclusion, T-CEA expression appears to be an important prognostic factor in early stage SSC of the lung.

AB - High levels of serum carcinoembryonic antigen (S-CEA) are considered a negative prognostic factor in non-small-cell lung cancer (NSCLC), while the prognostic value of tumour CEA (T-CEA) is unknown. We investigated the prognostic role of T-CEA in radically resected early stage NSCLC. We measured preoperative S-CEA levels and T-CEA in 146 patients with stage 1-2 NSCLC, and analysed their influence on survival. In patients positive for T-CEA, 3-year survival was 80%, compared to 65% in T-CEA-negative patients (p = 0.03). After stratification by histology, T-CEA positivity was prognostic of better survival in squamous cell carcinoma (SCC) (p = 0.024) but not in adenocarcinomas (ADK) (p = 0.87). Multiple Cox regression analysis showed that T-CEA positivity was an independent predictor of better survival in patients with early stage NSCLC (p = 0.02). In SCC patients, the magnitude of the hazard ratio was confirmed even if the precision of the estimate is decreased (p = 0.06). In conclusion, T-CEA expression appears to be an important prognostic factor in early stage SSC of the lung.

KW - CEA

KW - Lung cancer

KW - Prognostic factors

KW - Squamous cell carcinoma

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