Tumour-derived extracellular vesicles (EVs): A dangerous “message in a bottle” for bone

Alfredo Cappariello, Nadia Rucci

Research output: Contribution to journalReview article

Abstract

Several studies have shown the importance of Extracellular Vesicles (EVs) in the intercellular communication between tumour and resident cells. Through EVs, tumour cells can trigger cell-signalling molecules and shuttle exogenous information to target cells, thus promoting spread of the disease. In fact, many processes are fuelled by EVs, such as tumour invasion and dormancy, drug-resistance, immune-surveillance escape, extravasation, extracellular matrix remodelling and metastasis. A key element is certainly the molecular profile of the shed cargo. Understanding the biochemical basis of EVs would help to predict the ability and propensity of cancer cells to metastasize a specific tissue, with the aim to target the release of EVs and to manipulate their content as a possible therapeutic approach. Moreover, EV profiling could help monitor the progression of cancer, providing a useful tool for more effective therapy. This review will focus on all the EV-mediated mentioned mechanisms in the context of both primary bone cancers and bone metastases.

Original languageEnglish
Article number4805
JournalInternational Journal of Molecular Sciences
Volume20
Issue number19
DOIs
Publication statusPublished - Oct 1 2019

Keywords

  • Bone metastases
  • Bone tumour
  • Extracellular vesicles
  • Osteosarcoma

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Fingerprint Dive into the research topics of 'Tumour-derived extracellular vesicles (EVs): A dangerous “message in a bottle” for bone'. Together they form a unique fingerprint.

  • Cite this