Tumour-derived extracellular vesicles (EVs): A dangerous “message in a bottle” for bone

Alfredo Cappariello, Nadia Rucci

Research output: Contribution to journalReview articlepeer-review

Abstract

Several studies have shown the importance of Extracellular Vesicles (EVs) in the intercellular communication between tumour and resident cells. Through EVs, tumour cells can trigger cell-signalling molecules and shuttle exogenous information to target cells, thus promoting spread of the disease. In fact, many processes are fuelled by EVs, such as tumour invasion and dormancy, drug-resistance, immune-surveillance escape, extravasation, extracellular matrix remodelling and metastasis. A key element is certainly the molecular profile of the shed cargo. Understanding the biochemical basis of EVs would help to predict the ability and propensity of cancer cells to metastasize a specific tissue, with the aim to target the release of EVs and to manipulate their content as a possible therapeutic approach. Moreover, EV profiling could help monitor the progression of cancer, providing a useful tool for more effective therapy. This review will focus on all the EV-mediated mentioned mechanisms in the context of both primary bone cancers and bone metastases.

Original languageEnglish
Article number4805
JournalInternational Journal of Molecular Sciences
Volume20
Issue number19
DOIs
Publication statusPublished - Oct 1 2019

Keywords

  • Bone metastases
  • Bone tumour
  • Extracellular vesicles
  • Osteosarcoma

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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