TY - JOUR
T1 - Tumour markers and FDG PET/CT for prediction of disease relapse in patients with breast cancer
AU - Evangelista, Laura
AU - Baretta, Zora
AU - Vinante, Lorenzo
AU - Cervino, Anna Rita
AU - Gregianin, Michele
AU - Ghiotto, Cristina
AU - Saladini, Giorgio
AU - Sotti, Guido
PY - 2011/2
Y1 - 2011/2
N2 - Purpose: The aim of the study was to assess the role of CA 15.3, CT and positron emission tomography (PET)/CT in patients with breast cancer and suspected disease relapse after primary treatment. Methods: We studied 111 consecutive patients (mean age 61±12 years) with previous breast cancer, already treated and with clinical or biochemical suspicion of disease relapse. All patients underwent CT and
18F-fluorodeoxyglucose (FDG) PET/CT. In all patients, the value of CA 15.3 was compared to PET/CT and CT. The final diagnosis of relapse was established by invasive and noninvasive follow-up and was compared with CA 15.3, CT and PET/CT results. Univariate and multivariate analyses were used to identify the independent predictors of disease relapse and receiver-operating characteristic (ROC) curve for the identification of optimal CA 15.3 cutoff. Results: Of all patients, 40 (36%) showed an increased CA 15.3 value, CT was positive in 73 (66%), whereas at PET/CT imaging 64 (58%) showed positive findings for disease relapse. Of 40 patients with increased marker levels, 22 patients had positive CT and 30 positive PET/CT (55 vs 75%, p
AB - Purpose: The aim of the study was to assess the role of CA 15.3, CT and positron emission tomography (PET)/CT in patients with breast cancer and suspected disease relapse after primary treatment. Methods: We studied 111 consecutive patients (mean age 61±12 years) with previous breast cancer, already treated and with clinical or biochemical suspicion of disease relapse. All patients underwent CT and
18F-fluorodeoxyglucose (FDG) PET/CT. In all patients, the value of CA 15.3 was compared to PET/CT and CT. The final diagnosis of relapse was established by invasive and noninvasive follow-up and was compared with CA 15.3, CT and PET/CT results. Univariate and multivariate analyses were used to identify the independent predictors of disease relapse and receiver-operating characteristic (ROC) curve for the identification of optimal CA 15.3 cutoff. Results: Of all patients, 40 (36%) showed an increased CA 15.3 value, CT was positive in 73 (66%), whereas at PET/CT imaging 64 (58%) showed positive findings for disease relapse. Of 40 patients with increased marker levels, 22 patients had positive CT and 30 positive PET/CT (55 vs 75%, p
KW - Breast cancer
KW - Disease relapse
KW - Follow-up
KW - Positron emission tomography
KW - Tumour markers
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U2 - 10.1007/s00259-010-1626-7
DO - 10.1007/s00259-010-1626-7
M3 - Article
C2 - 20882280
AN - SCOPUS:79551559469
VL - 38
SP - 293
EP - 301
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
SN - 0340-6199
IS - 2
ER -